Protein Alignment VLDLR and arr

DIOPT Version :10

• Sequence 1: NP_003374.3
• Gene: VLDLR / 7436
• HGNCID: 12698
• Length: 873
• Species: Homo sapiens
• Sequence 2: NP_524737.2
• Gene: arr / 44279
• FlyBaseID: FBgn0000119
• Length: 1678
• Species: Drosophila melanogaster
• Alignment Length: 455
• Identity: 135/455 - (29%)
• Similarity: 205/455 - (45%)
• Gaps: 71/455 - (15%)

Human   330 ECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVI----GYECDCAAGFELID 390
            |.||..|..|   ..|.| |..|:....|.|..|||.|||:|  |:.    |:.|.|..|.:||.
  Fly   335 ELIDTPKAPN---SVRAW-DPSLQPYEDNPCAHNNGNCSHLC--LLATNSQGFSCACPTGVKLIS 393

Human   391 RKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIG 455
            ..||                                         |.|.:..:....|..|.||.
  Fly   394 ANTC-----------------------------------------ANGSQEMMFIVQRTQISKIS 417

Human   456 LERKEYIQL---VEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVK--MIDNVYNP 515
            |:..:|...   :.:::..:|:|.|...:.::|:|:....|..|..|   |..|.  :...|.:|
  Fly   418 LDSPDYTIFPLPLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHAD---GTGVTDFVTSEVRHP 479

Human   516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGE-PA 579
            ..:|:||:.:.:||||..:..|.|..||||.||.|....|.||.:|||.|..|:::||||.| ..
  Fly   480 DGLALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDWNERKP 544

Human   580 KIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFL 644
            |:|:|.::|.:|..||:.::.|||||.||:....:||.|.|...:...:::|..||:|:.  :.|
  Fly   545 KVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVIS--DNL 607

Human   645 AHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEED 709
            .|...|:|.:|.:||.|.:..::..|:|.||:....:|:...|...:.| ..|.:..|:|.|.
  Fly   608 KHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPDLMGLKV-TRLREVRGQNACA-- 669

Human   710 MENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEISATSG 774
            :.||||.:|||..|:      .|.|.|...|.:..:.|.|...|..:.:|..:......|....|
  Fly   670 VRNGGCSHLCLNRPR------DYVCRCAIDYELANDKRTCVVPAAFLLFSRQEHIGRISIEYNEG 728

Human   775  774
              Fly   729  728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VLDLR	NP_003374.3	LDLa	33..67	CDD:238060
		LDLa	71..103	CDD:197566
		Ldl_recept_a	111..149	CDD:395011
		LDLa	154..188	CDD:238060
		Ldl_recept_a	192..224	CDD:395011
		Ldl_recept_a	237..273	CDD:395011
		Ldl_recept_a	276..312	CDD:395011
		Ldl_recept_a	320..350	CDD:395011	7/19 (37%)
		FXa_inhibition	360..394	CDD:464251	15/37 (41%)
		EGF_CA	396..426	CDD:214542	0/29 (0%)
		Ldl_recept_b	481..522	CDD:459654	10/42 (24%)
		LY	505..547	CDD:214531	16/43 (37%)
		Ldl_recept_b	568..608	CDD:459654	18/40 (45%)
		LY	592..634	CDD:214531	14/41 (34%)
		Ldl_recept_b	655..695	CDD:459654	11/39 (28%)
		FXa_inhibition	706..749	CDD:464251	14/42 (33%)
arr	NP_524737.2	LY	162..201	CDD:214531
		NHL	168..503	CDD:302697	55/217 (25%)
		NHL repeat	172..237	CDD:271320
		LY	252..293	CDD:214531
		NHL repeat	261..298	CDD:271320
		NHL repeat	303..339	CDD:271320	2/3 (67%)
		NHL repeat	341..419	CDD:271320	30/124 (24%)
		NHL repeat	428..476	CDD:271320	10/50 (20%)
		LY	472..511	CDD:214531	15/38 (39%)
		NHL repeat	477..503	CDD:271320	9/25 (36%)
		Ldl_recept_b	534..574	CDD:459654	18/39 (46%)
		LY	558..599	CDD:214531	14/40 (35%)
		LY	600..641	CDD:214531	14/42 (33%)
		FXa_inhibition	668..703	CDD:464251	14/42 (33%)
		YncE	<736..886	CDD:442618
		LY	776..818	CDD:214531
		LY	905..946	CDD:214531
		FXa_inhibition	973..1010	CDD:464251
		YncE	<1047..1191	CDD:442618
		LDLa	1319..1362	CDD:238060
		LDLa	1365..1399	CDD:238060
		LDLa	1399..1433	CDD:197566