DRSC/TRiP Functional Genomics Resources

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Protein Alignment VLDLR and frac

DIOPT Version :10

Sequence 1:NP_003374.3 Gene:VLDLR / 7436 HGNCID:12698 Length:873 Species:Homo sapiens
Sequence 2:NP_648137.3 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster


Alignment Length:936 Identity:194/936 - (20%)
Similarity:299/936 - (31%) Gaps:395/936 - (42%)


- Green bases have known domain annotations that are detailed below.


Human    42 NGRCI----TLLW--------KCDGDED-CVDGSDEKNCVK-KTCAESDFVCNNGQC------VP 86
            ||.|.    .||:        |||..|. .:|.:|..:|:. ..|.||     ||.|      :|
  Fly   252 NGGCAHICKRLLYPDENQPINKCDCREGYTLDPNDYASCLDIDECLES-----NGGCSEICENLP 311

Human    87 SRWKCDGDPDCEDG--SDESPEQC-HMRTCRIHEISCGAH-STQCIPVSWRC--DGENDCDSGED 145
            ..:||    .|::|  .|||.:.| .:..|...|:|.... :.:.:|.|:||  ..|.:.:..|.
  Fly   312 GEYKC----SCQEGYYLDESGKSCVDINECANPELSSNCQGACENLPGSYRCVEPLEENPEITEV 372

Human   146 EEN--------CGNITCS-PDEFTCSSGRCISRNFV-CNGQDDCS-DGSDELD----C---APPT 192
            .||        ..|::.| |...||:||..:|.:.. |...::|. ||.::||    |   ...|
  Fly   373 VENPIEKTNEVPVNVSESQPAGKTCNSGFQLSADGTDCQDINECEVDGPEDLDNNAVCQQKCENT 437

Human   193 CGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLE--QCGRQPVIH-----------TKCP---- 240
            .|:  |:|   :|:....:.:|...|:..|...||  |..|....|           ..||    
  Fly   438 IGS--FRC---TCVEGYHLLEDQRSCALDSCTDLENPQLNRTRCAHECQDLPEGSYRCVCPKGYE 497

Human   241 ASEIQ------------------CGSGECI-----------------HKKWRCDGDPDCKDGSDE 270
            .||.|                  |..|.|:                 .:.:.|....:|   :::
  Fly   498 LSEDQHSCLVQESPCSTEKGVEKCSPGTCLASEDNTSFSCICPTGYRSEAFSCQDIDEC---AED 559

Human   271 VNCPSRTCR--PDQFEC---------EDGSCI---------HGSRQ-C----NGIRDCVDG---- 306
            .:..|.||:  |..::|         |:.:|:         :|..| |    .|:..|.:|    
  Fly   560 THLCSHTCQNTPGGYQCQCPEGLNLVEEYTCLAENLCEVNNNGCEQICLTARGGVCACREGFRLS 624

Human   307 SDEVNCKNVNQCLG------------PGKFKC-------------RSGECIDISKVCNQEQDCRD 346
            :|..:|::|::||.            ||.:.|             ..|.|.||.:...:...|  
  Fly   625 ADGKSCEDVDECLVNNGGCQQVCRNLPGSYGCICAAGYELLKLDGIRGYCFDIDECSQRTHGC-- 687

Human   347 WSDEPLKE--------------------------------------------C-HINECLVNNGG 366
             ||:.|.|                                            | .|:||.:.||.
  Fly   688 -SDQMLCENLNGSYTCLCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTCLDIDECSLANGN 751

Human   367 CSHICKDLVIGYECDCAAGFELI-DRKTCGDIDEC-QNPGICSQICINLKGGYKCECSRGYQMDL 429
            |||.|::...|::|.|..|:.|. |.:||.||||| .:.|.|||:|:|..||:.|.|..|:::..
  Fly   752 CSHFCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQCSQLCLNQPGGFACACETGFELTP 816

Human   430 ATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKA-I 493
            ....|..: .|.|..:.|..||         .|.|:...........::|..||...|:.:.| :
  Fly   817 DGFGCADI-DECSQDYGNCSDI---------CINLLGTHACACERGYELAKDKLSCLDVDECAGL 871

Human   494 FSASID----DKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLD-GTKRKFLFNS 553
            .|....    :|.|                                     |.: |....::.|.
  Fly   872 LSGGCSHECINKAG-------------------------------------TFECGCPLGYILND 899

Human   554 DLR--EPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYW 616
            |.|  .||.:...|                      |..|.....|.|:...|.||         
  Fly   900 DGRSCSPALVGCPP----------------------GTQRSADGCAPIECNPGYTL--------- 933

Human   617 LDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATL 681
                          |.|.:.|                                            
  Fly   934 --------------GSDDKCV-------------------------------------------- 940

Human   682 VNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENG 746
                    ||            :.|::  :||||.:.|      ::....:.||||.||.::.:.
  Fly   941 --------DI------------DECQK--QNGGCSHRC------SNTEGSFKCSCPPGYELDSDQ 977

Human   747 RDCQSTATTVTYSETKDTNTTEISAT 772
            :.||.      ..|.....|:.|:.|
  Fly   978 KTCQD------IDECDQDKTSCITGT 997

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VLDLRNP_003374.3 LDLa 33..67 CDD:238060 11/37 (30%)
LDLa 71..103 CDD:197566 11/39 (28%)
Ldl_recept_a 111..149 CDD:395011 11/48 (23%)
LDLa 154..188 CDD:238060 13/40 (33%)
Ldl_recept_a 192..224 CDD:395011 8/31 (26%)
Ldl_recept_a 237..273 CDD:395011 10/74 (14%)
Ldl_recept_a 276..312 CDD:395011 13/64 (20%)
Ldl_recept_a 320..350 CDD:395011 9/54 (17%)
FXa_inhibition 360..394 CDD:464251 13/34 (38%)
EGF_CA 396..426 CDD:214542 16/30 (53%)
Ldl_recept_b 481..522 CDD:459654 7/45 (16%)
LY 505..547 CDD:214531 2/42 (5%)
Ldl_recept_b 568..608 CDD:459654 6/39 (15%)
LY 592..634 CDD:214531 6/41 (15%)
Ldl_recept_b 655..695 CDD:459654 2/39 (5%)
FXa_inhibition 706..749 CDD:464251 12/42 (29%)
fracNP_648137.3 FXa_inhibition 296..331 CDD:464251 14/43 (33%)
cEGF 396..415 CDD:463661 6/18 (33%)
FXa_inhibition 425..458 CDD:464251 8/37 (22%)
FXa_inhibition 476..505 CDD:464251 6/28 (21%)
EGF_CA 552..>581 CDD:214542 6/31 (19%)
FXa_inhibition 596..630 CDD:464251 7/33 (21%)
FXa_inhibition 636..>664 CDD:464251 5/27 (19%)
EGF_CA 676..711 CDD:214542 7/37 (19%)
FXa_inhibition 745..780 CDD:464251 13/34 (38%)
FXa_inhibition 786..821 CDD:464251 12/34 (35%)
vWFA <821..861 CDD:469594 10/49 (20%)
FXa_inhibition 874..904 CDD:464251 7/66 (11%)
FXa_inhibition 945..980 CDD:464251 12/42 (29%)
PTZ00449 <1017..>1098 CDD:185628
CCP 1110..1170 CDD:153056
CCP 1183..1235 CDD:153056
HYR 1468..1536 CDD:460572
Blue background indicates that the domain is not in the aligned region.

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