DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VLDLR and yl

DIOPT Version :9

Sequence 1:	NP_003374.3	Gene:	VLDLR / 7436	HGNCID:	12698	Length:	873	Species:	Homo sapiens
Sequence 2:	NP_996433.1	Gene:	yl / 32367	FlyBaseID:	FBgn0004649	Length:	1984	Species:	Drosophila melanogaster

Alignment Length:	775	Identity:	238/775 - (30%)
Similarity:	348/775 - (44%)	Gaps:	162/775 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    22 SGATGTGRKAKCEPSQFQCTNGR-----CITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNN 81
            ||.:.:.|...|:.:.. ..|||     .:.|:..|.|......||.:..     |....|.|.:
  Fly    41 SGGSTSSRYGNCQRTHL-IINGRHVAISLLLLVGLCGGTAAGTPGSADTR-----CDAGQFQCRD 99

Human    82 GQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDE 146
            |.|:.....|||..||:|.|||.  .|..|.||              |..|
  Fly   100 GGCILQAKMCDGRGDCKDSSDEL--DCDYRLCR--------------PPHW-------------- 134

Human   147 ENCGNITCSPDEFTCSS--GRCISRNFVCNGQDDCSDGSDELDC-APP------------TCGAH 196
                        |.|:.  |.|::...:|||.|:|..|.|||:| ..|            :|..:
  Fly   135 ------------FPCAQPHGACLAAELMCNGIDNCPGGEDELNCPVRPGFRFGDTAHRMRSCSKY 187

Human   197 EFQCSTS-SCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKK-WRCD 259
            ||.|... :||||.::||...||:|:||| :..|.:..:   .||.....|.:|.|:.:| |.||
  Fly   188 EFMCQQDRTCIPIDFMCDGRPDCTDKSDE-VAGCKQAEI---TCPGEGHLCANGRCLRRKQWVCD 248

Human   260 GDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKF 324
            |..||.|||||..| ...|.|.:                                       |||
  Fly   249 GVDDCGDGSDERGC-LNLCEPQK---------------------------------------GKF 273

Human   325 KCRSGE-CIDISKVCNQEQDCRDWSDE-----PLKECHINECLVNNGGCSHICKDLVIGYECDCA 383
            .||:.| |:.:|:||:...||.|.|||     ...:|...:|.:  |...|:..  ..|.||.|.
  Fly   274 LCRNRETCLTLSEVCDGHSDCSDGSDETDLCHSKPDCDAKKCAL--GAKCHMMP--ASGAECFCP 334

Human   384 AGFELID-RKTCGDIDEC-QNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAV-----GKEP 441
            .||.|.. ...|.|:||| :...:|||.|.|..|||:|.|..||.:|.....|:||     .::|
  Fly   335 KGFRLAKFEDKCEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLDKDNRTCRAVVYGSKEQQP 399

Human   442 SLIFTNRRDIRKIGLE----RKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKA--IFSASIDD 500
            .|::|.:..|..:.|.    |....|:...|...:.:..|  ...::|.::..:|  |..|: .|
  Fly   400 LLLYTTQMTIMGMHLREDNVRNHVYQVAGNLSKVIGVAYD--GSHIYWTNIQNEAESIVKAN-GD 461

Human   501 KVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDP 565
            .....:.:...:..|..:||||:.:.||::|...:.|:|.:.||.....|...|:.:|.|:||.|
  Fly   462 GSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQPRSLAVWP 526

Human   566 LSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLN 630
            ..|.::|:||||...|.:|.|:|...||:|:.:|:|||||.||:.:.|:||:|:||..:.:|..:
  Fly   527 QKGLMFWTDWGEKPMIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPD 591

Human   631 GQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQD----- 690
            |..||.||..:  |.||..|.||||::||.|...::|:..:||:|.:...|      |:|
  Fly   592 GTGRRTVLDGM--LKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHRIL------AKDRTIYA 648

Human   691 IIVYHELVQPSGKNWCEEDMENGGCEYLCLPA-PQINDHSPKYTCSCPSGYNVEENGRDC 749
            :.:||...||:..:.|    ||..|.:|||.| |:|..||    |:||.|..:..:.|.|
  Fly   649 VHIYHPAKQPNSPHGC----ENATCSHLCLLAEPEIGGHS----CACPDGMRLAPDHRRC 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VLDLR	NP_003374.3	LDLa	33..67	CDD:238060	9/38 (24%)
		LDLa	71..103	CDD:197566	12/31 (39%)
		Ldl_recept_a	111..149	CDD:278486	5/37 (14%)
		LDLa	154..188	CDD:238060	13/35 (37%)
		Ldl_recept_a	192..224	CDD:278486	14/32 (44%)
		Ldl_recept_a	237..273	CDD:278486	17/36 (47%)
		Ldl_recept_a	276..312	CDD:278486	2/35 (6%)
		Ldl_recept_a	320..350	CDD:278486	14/30 (47%)
		FXa_inhibition	360..394	CDD:291342	10/34 (29%)
		EGF_CA	396..426	CDD:214542	15/30 (50%)
		Ldl_recept_b	481..521	CDD:278487	7/41 (17%)
		LY	505..547	CDD:214531	12/41 (29%)
		Ldl_recept_b	568..608	CDD:278487	19/39 (49%)
		LY	592..634	CDD:214531	19/41 (46%)
		Ldl_recept_b	655..694	CDD:278487	11/43 (26%)
		FXa_inhibition	706..749	CDD:291342	17/43 (40%)
		Mucin	<751..813	CDD:250634
yl	NP_996433.1	LDLa	90..124	CDD:238060	14/35 (40%)
		LDLa	131..166	CDD:238060	15/60 (25%)
		LDLa	184..216	CDD:238060	14/31 (45%)
		LDLa	227..262	CDD:238060	17/34 (50%)
		LDLa	271..302	CDD:238060	16/30 (53%)
		FXa_inhibition	352..387	CDD:291342	14/34 (41%)
		Ldl_recept_b	442..482	CDD:278487	7/40 (18%)
		LY	466..508	CDD:214531	12/41 (29%)
		Ldl_recept_b	529..569	CDD:278487	19/39 (49%)
		LY	553..595	CDD:214531	19/41 (46%)
		LY	596..637	CDD:214531	18/42 (43%)
		FXa_inhibition	669..700	CDD:291342	14/34 (41%)
		LY	774..815	CDD:214531
		LDLa	1032..1062	CDD:238060
		LDLa	1074..1109	CDD:238060
		LDLa	1118..1152	CDD:238060
		LDLa	1157..1189	CDD:197566
		LDLa	1198..1232	CDD:238060
		LDLa	1243..1279	CDD:238060
		LDLa	1283..1318	CDD:238060
		LDLa	1340..1371	CDD:197566
		FXa_inhibition	1388..1416	CDD:291342
		EGF_CA	1418..1452	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810