DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrtm1 and Fili

DIOPT Version :9

Sequence 1:	NP_001349038.1	Gene:	Lrrtm1 / 74342	MGIID:	2389173	Length:	522	Species:	Mus musculus
Sequence 2:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	613	Identity:	138/613 - (22%)
Similarity:	233/613 - (38%)	Gaps:	149/613 - (24%)

- Green bases have known domain annotations that are detailed below.

Mouse    20 VVLCLLGACFQMLPAAPSGCPGQCRCEGRLLYCEALNLTEAPHNLSGLLGLSLRYNSL--SELRA 82
            |:|.||.....:.|...:.||.:|:|.|......||.:..|..::...|....:|.:|  :.:|.
  Fly    23 VLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIRT 87

Mouse    83 GQFT--GLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITELANTTFRPMPNLRSVDLS 145
            .:|:  ..|:|..|.|..|.|.::....|:....::.|.||.|.::.|....|:.:.||..:|||
  Fly    88 LEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLS 152

Mouse   146 YNKLQALAP------------DL------------FHGLRKLTTLHMRANAIQFVPVRIFQDCRS 186
            :|:::.:.|            ||            |.|:..|..|..|.|.:..||........:
  Fly   153 FNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLHA 217

Mouse   187 LKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLIKVNFAHFPRLISLHSLCLRRNKVAIV-VS 250
            ||.||:..|.::.:..:||.||.:|..|.::.|.:.:::.:.|..||||..|.|..|.:.:| ..
  Fly   218 LKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQ 282

Mouse   251 SLDWVWNLEKMDLSGNE-------------------------IEYMEPHVFETVPYLQTLQLDSN 290
            .|..:.||..::|.||.                         ::.::...|....:||||.|::|
  Fly   283 QLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLNNN 347

Mouse   291 --------RLTYIEPRIL------NSWKSLTS----------ITLAGNLWDCGRNVCALASWL-- 329
                    ||....|.||      ||.::|.|          :.|..|...|.   |:|. ||
  Fly   348 PQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCN---CSLL-WLWR 408

Mouse   330 ---SNFQGRYDANLQ-------CASPEYAQGEDVLDAVYAFHLCEDGAEPTSGHLLSVAVTNRSD 384
               .||:| .|..::       .|..:.|..|::.|...|....:||....:.::....:.|...
  Fly   409 LVTGNFEG-VDPGMEHAAGGAVAALAKEADDEELADEATAVASTDDGVAALAAYIAEQHIVNALH 472

Mouse   385 LTPPESSATTLVDGGEGHDGTFEPITVALPGGEHAENAVQIHK---------------VVTGTMA 434
            .|.|  ||..|.......:.....:.....|.:...:.|:..:               :||...|
  Fly   473 TTEP--SAYELATSSSNRNSGILRMDRQQIGCDIWRDKVRTRRKLLTMSEGEITCPAHIVTVVCA 535

Mouse   435 LIFSFLIVVLVLYVSWKCFPASLRQLRQCFVTQRRKQKQKQTMHQMAAMSAQEYYVD-------- 491
            :|...|:.::.:.|        |..||  ||.:|||     .:|:...|...:..::
  Fly   536 VITCLLVAMIGISV--------LYYLR--FVKRRRK-----LLHERGPMRTSKSIINVHDRILQG 585

Mouse   492 YKP--------------NHIEGALVIIN 505
            :.|              ||:.|..:.:|
  Fly   586 HNPGGLGLGMSMTLGGGNHVNGLGMTLN 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrtm1	NP_001349038.1	LRR 1	64..87		5/26 (19%)
		LRR	<75..>315	CDD:227223	77/317 (24%)
		LRR 2	89..111		7/21 (33%)
		leucine-rich repeat	91..114	CDD:275380	6/22 (27%)
		LRR 3	112..135		6/22 (27%)
		leucine-rich repeat	115..138	CDD:275380	6/22 (27%)
		LRR 4	136..159		10/46 (22%)
		leucine-rich repeat	139..162	CDD:275380	10/46 (22%)
		LRR 5	161..183		6/21 (29%)
		leucine-rich repeat	163..186	CDD:275380	6/22 (27%)
		LRR 6	184..207		7/22 (32%)
		leucine-rich repeat	187..210	CDD:275380	9/22 (41%)
		LRR 7	209..231		4/21 (19%)
		leucine-rich repeat	211..234	CDD:275380	5/22 (23%)
		LRR 8	233..255		8/22 (36%)
		leucine-rich repeat	235..257	CDD:275380	6/22 (27%)
		LRR 9	256..278		6/46 (13%)
		leucine-rich repeat	258..281	CDD:275380	5/47 (11%)
		LRR 10	280..302		11/35 (31%)
		leucine-rich repeat	282..300	CDD:275380	9/25 (36%)
		leucine-rich repeat	306..318	CDD:275378	4/21 (19%)
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	4/21 (19%)
		leucine-rich repeat	98..121	CDD:275380	6/22 (27%)
		LRR_8	120..180	CDD:404697	15/59 (25%)
		leucine-rich repeat	122..145	CDD:275380	6/22 (27%)
		leucine-rich repeat	146..169	CDD:275380	6/22 (27%)
		LRR	<161..>354	CDD:227223	45/192 (23%)
		leucine-rich repeat	170..193	CDD:275380	4/22 (18%)
		leucine-rich repeat	194..217	CDD:275380	6/22 (27%)
		leucine-rich repeat	218..265	CDD:275380	14/46 (30%)
		leucine-rich repeat	266..289	CDD:275380	6/22 (27%)
		leucine-rich repeat	290..313	CDD:275380	4/22 (18%)
		leucine-rich repeat	314..338	CDD:275380	1/23 (4%)
		LRR_8	337..397	CDD:404697	17/59 (29%)
		leucine-rich repeat	339..360	CDD:275380	8/20 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100