Protein Alignment Lrrtm1 and Fili

DIOPT Version :10

• Sequence 1: NP_083156.2
• Gene: Lrrtm1 / 74342
• MGIID: 2389173
• Length: 522
• Species: Mus musculus
• Sequence 2: NP_001369108.1
• Gene: Fili / 5740472
• FlyBaseID: FBgn0085397
• Length: 789
• Species: Drosophila melanogaster
• Alignment Length: 613
• Identity: 138/613 - (22%)
• Similarity: 233/613 - (38%)
• Gaps: 149/613 - (24%)

Mouse    20 VVLCLLGACFQMLPAAPSGCPGQCRCEGRLLYCEALNLTEAPHNLSGLLGLSLRYNSL--SELRA 82
            |:|.||.....:.|...:.||.:|:|.|......||.:..|..::...|....:|.:|  :.:|.
  Fly    23 VLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIRT 87

Mouse    83 GQFT--GLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITELANTTFRPMPNLRSVDLS 145
            .:|:  ..|:|..|.|..|.|.::....|:....::.|.||.|.::.|....|:.:.||..:|||
  Fly    88 LEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLS 152

Mouse   146 YNKLQALAP------------DL------------FHGLRKLTTLHMRANAIQFVPVRIFQDCRS 186
            :|:::.:.|            ||            |.|:..|..|..|.|.:..||........:
  Fly   153 FNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLHA 217

Mouse   187 LKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLIKVNFAHFPRLISLHSLCLRRNKVAIV-VS 250
            ||.||:..|.::.:..:||.||.:|..|.::.|.:.:::.:.|..||||..|.|..|.:.:| ..
  Fly   218 LKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQ 282

Mouse   251 SLDWVWNLEKMDLSGNE-------------------------IEYMEPHVFETVPYLQTLQLDSN 290
            .|..:.||..::|.||.                         ::.::...|....:||||.|::|
  Fly   283 QLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLNNN 347

Mouse   291 --------RLTYIEPRIL------NSWKSLTS----------ITLAGNLWDCGRNVCALASWL-- 329
                    ||....|.||      ||.::|.|          :.|..|...|.   |:|. ||
  Fly   348 PQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCN---CSLL-WLWR 408

Mouse   330 ---SNFQGRYDANLQ-------CASPEYAQGEDVLDAVYAFHLCEDGAEPTSGHLLSVAVTNRSD 384
               .||:| .|..::       .|..:.|..|::.|...|....:||....:.::....:.|...
  Fly   409 LVTGNFEG-VDPGMEHAAGGAVAALAKEADDEELADEATAVASTDDGVAALAAYIAEQHIVNALH 472

Mouse   385 LTPPESSATTLVDGGEGHDGTFEPITVALPGGEHAENAVQIHK---------------VVTGTMA 434
            .|.|  ||..|.......:.....:.....|.:...:.|:..:               :||...|
  Fly   473 TTEP--SAYELATSSSNRNSGILRMDRQQIGCDIWRDKVRTRRKLLTMSEGEITCPAHIVTVVCA 535

Mouse   435 LIFSFLIVVLVLYVSWKCFPASLRQLRQCFVTQRRKQKQKQTMHQMAAMSAQEYYVD-------- 491
            :|...|:.::.:.|        |..||  ||.:|||     .:|:...|...:..::
  Fly   536 VITCLLVAMIGISV--------LYYLR--FVKRRRK-----LLHERGPMRTSKSIINVHDRILQG 585

Mouse   492 YKP--------------NHIEGALVIIN 505
            :.|              ||:.|..:.:|
  Fly   586 HNPGGLGLGMSMTLGGGNHVNGLGMTLN 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lrrtm1	NP_083156.2	LRR	49..>315	CDD:443914	82/343 (24%)
		LRR 1	64..87		5/26 (19%)
		LRR 2	89..111		7/21 (33%)
		leucine-rich repeat	91..114	CDD:275380	6/22 (27%)
		LRR 3	112..135		6/22 (27%)
		leucine-rich repeat	115..138	CDD:275380	6/22 (27%)
		LRR 4	136..159		10/46 (22%)
		leucine-rich repeat	139..162	CDD:275380	10/46 (22%)
		LRR 5	161..183		6/21 (29%)
		leucine-rich repeat	163..186	CDD:275380	6/22 (27%)
		LRR 6	184..207		7/22 (32%)
		leucine-rich repeat	187..210	CDD:275380	9/22 (41%)
		LRR 7	209..231		4/21 (19%)
		leucine-rich repeat	211..234	CDD:275380	5/22 (23%)
		LRR 8	233..255		8/22 (36%)
		leucine-rich repeat	235..257	CDD:275380	6/22 (27%)
		LRR 9	256..278		6/46 (13%)
		leucine-rich repeat	258..281	CDD:275380	5/47 (11%)
		LRR 10	280..302		11/35 (31%)
		leucine-rich repeat	282..300	CDD:275380	9/25 (36%)
		leucine-rich repeat	306..318	CDD:275378	4/21 (19%)
Fili	NP_001369108.1	LRR	71..>348	CDD:443914	68/276 (25%)
		leucine-rich repeat	75..97	CDD:275378	4/21 (19%)
		leucine-rich repeat	98..121	CDD:275380	6/22 (27%)
		leucine-rich repeat	122..145	CDD:275380	6/22 (27%)
		leucine-rich repeat	146..169	CDD:275380	6/22 (27%)
		leucine-rich repeat	170..193	CDD:275380	4/22 (18%)
		leucine-rich repeat	194..217	CDD:275380	6/22 (27%)
		leucine-rich repeat	218..265	CDD:275380	14/46 (30%)
		leucine-rich repeat	266..289	CDD:275380	6/22 (27%)
		leucine-rich repeat	290..313	CDD:275380	4/22 (18%)
		leucine-rich repeat	314..338	CDD:275380	1/23 (4%)
		LRR_8	337..397	CDD:404697	17/59 (29%)
		leucine-rich repeat	339..360	CDD:275380	8/20 (40%)