DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rnf145 and HRD1

DIOPT Version :9

Sequence 1:	NP_001350095.1	Gene:	Rnf145 / 74315	MGIID:	1921565	Length:	663	Species:	Mus musculus
Sequence 2:	NP_014630.1	Gene:	HRD1 / 854149	SGDID:	S000005373	Length:	551	Species:	Saccharomyces cerevisiae

Alignment Length:	440	Identity:	92/440 - (20%)
Similarity:	165/440 - (37%)	Gaps:	96/440 - (21%)

- Green bases have known domain annotations that are detailed below.

Mouse   182 EVLYFLGSNLLVPYNLAKSAYRELVQVVEVYGLLALGMSLWNQLVVPVLFM----VFWLVLFALQ 242
            ::..|:....|:.:....||.:..|..::|...|..|   :|.:|:.:..:    :.|.:|..|
Yeast     9 QLAIFVVVTYLLTFYCVYSATKTSVSFLQVTLKLNEG---FNLMVLSIFILLNSTLLWQLLTKL- 69

Mouse   243 IYSYFSTRDQPASRERLLF-----LFLTSIAECCSTPYSLLGLVFTVSFVALGVLTLCKFYLQGY 302
            ::......:.....|||.|     ||::|:..   ..|     .|||:|  .|:|.|   ||:.:
Yeast    70 LFGELRLIEHEHIFERLPFTIINTLFMSSLFH---ERY-----FFTVAF--FGLLLL---YLKVF 121

Mouse   303 RAFMND--PAMNRGMTEGVTLLILAVQTGLIELQVVHRAFLLSIILFIVVASILQSMLEIADPIV 365
            ...:.|  .|:.:.:.:..|:..|........|      .||:::.:.::...:.|:.
Yeast   122 HWILKDRLEALLQSINDSTTMKTLIFSRFSFNL------VLLAVVDYQIITRCISSIY------- 173

Mouse   366 LALGASRDKSLWKHFRAVSLCLF-LLVFPAYMAYMICQFFH--MDFWLLIIISSSILTSLQVLGT 427
                 :..||   ...:.||.|. ::.|...:..::..|..  ::||       ....|.|.|..
Yeast   174 -----TNQKS---DIESTSLYLIQVMEFTMLLIDLLNLFLQTCLNFW-------EFYRSQQSLSN 223

Mouse   428 LFIYVLF-------MVEEFRKEPVENMDDVIYYVNGTYRLLE--FVVALCVVAYGVSETIFGEWT 483
            ...:::.       .||..:.:||.|.||.....:..:..||  |:....:..:    |.|.:..
Yeast   224 ENNHIVHGDPTDENTVESDQSQPVLNDDDDDDDDDRQFTGLEGKFMYEKAIDVF----TRFLKTA 284

Mouse   484 VMGSMIIFIHS--------YYNVWLRAQLGWKSFLLRRDAVNKIKSLPVATQEQLEKH-ND--IC 537
            :..||:|....        .:::....|.|...:.:.|:......:|...|.|||:.. ||  ||
Yeast   285 LHLSMLIPFRMPMMLLKDVVWDILALYQSGTSLWKIWRNNKQLDDTLVTVTVEQLQNSANDDNIC 349

Mouse   538 AICYQDM-------------KSAVITPCSHFFHAGCLKKWLYVQDTCPLC 574
            .||..::             |.....||.|..|..|||.|:....|||:|
Yeast   350 IICMDELIHSPNQQTWKNKNKKPKRLPCGHILHLSCLKNWMERSQTCPIC 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf145	NP_001350095.1	TRC8_N	8..506	CDD:372682	66/354 (19%)
		YLYF motif. /evidence=ECO:0000269\|PubMed:29374057	81..84
		HRD1	<520..627	CDD:227568	24/71 (34%)
		RING-H2_RNF145	533..575	CDD:319598	19/58 (33%)
		RING-H2 finger (C3H2C3-type)	537..574	CDD:319598	15/49 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..663
HRD1	NP_014630.1	HRD1	5..551	CDD:227568	92/440 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C158775298
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740