Protein Alignment Rnf145 and sip3

DIOPT Version :10

• Sequence 1: NP_083138.2
• Gene: Rnf145 / 74315
• MGIID: 1921565
• Length: 663
• Species: Mus musculus
• Sequence 2: NP_651894.3
• Gene: sip3 / 43747
• FlyBaseID: FBgn0039875
• Length: 626
• Species: Drosophila melanogaster
• Alignment Length: 453
• Identity: 106/453 - (23%)
• Similarity: 176/453 - (38%)
• Gaps: 108/453 - (23%)

Mouse   229 VLFMVFWLV--LFALQIYSYFSTRDQPASRERLLFLFLTSIAECCSTPYSLLGLVFTV------- 284
            |:::.|:::  :|...:...|....:.|..|.||..|..::.|.|        |.|||
  Fly    43 VIYIQFFVIVFMFGKLLSKIFLGTLRAAEFEHLLERFWYALTETC--------LAFTVFRDDFNP 99

Mouse   285 SFVALGVLTLCKFYLQGYRAFMNDPAMNRGMTEGVTLLILAVQTGLIELQVVHRAFLLSIILFIV 349
            .||||..:.|   :|:.:.....:                       .:..:.|:.:|..:..|.
  Fly   100 RFVALFTVLL---FLKSFHWLAEE-----------------------RVDFMERSPVLGWLFHIR 138

Mouse   350 VASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVFPAYMAYMI----CQF-FHMDFW 409
            |.|:| ::|.|.|                         ::|:..||.:.::    .|. |..::.
  Fly   139 VGSLL-TVLGILD-------------------------YVLLIHAYNSTLVRGPTVQLVFGFEYA 177

Mouse   410 LLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVNGTYRLLEFVVALC-VVAYG 473
            :|:.:.:|         |...|||...|.....|.||....:.|.       |.|:.|. ||.|.
  Fly   178 ILLTVIAS---------TAIKYVLHAAEMRTDTPWENKAVFLLYT-------ELVIGLIKVVLYI 226

Mouse   474 VSETIFGEWTVMGSMIIFIHSYYNVW-LRAQLGWKSFLLRRDAVNKIKSL-PVATQEQLEKHNDI 536
            :...|..:...: .|.:|...::.:. .|..|  ...::.|.|:..:.:| |.||.|:|.:.::|
  Fly   227 LFVVIMAKIYAL-PMFVFRPMFFTIRNFRKAL--NDVIMSRRAIRNMNTLYPDATPEELRQSDNI 288

Mouse   537 CAICYQDM-KSAVITPCSHFFHAGCLKKWLYVQDTCPLCHCHL-----KNSSQLPGLGTEAAPQP 595
            |.||.:|| ..:...||.|.||..||:.|...|.|||.|..::     .||:.:|..|.||.
  Fly   289 CIICREDMVNHSKKLPCGHIFHTTCLRSWFQRQQTCPTCRLNILRTPTVNSTAMPRQGDEAV--- 350

Mouse   596 PAGAEQNIVLQEGPEPPDHESPPG-TGTQEGSGDSSE-HINRGSASQEGAADA-GEGPQIPEG 655
            .|.|...|....|.:|.....||. |...:|:...:: ::..|.|.....||. |:...:|.|
  Fly   351 AAAAGNPIPAAAGVQPAGGVPPPAPTAVVDGNQARADVNVAGGQALPPNFADLFGDASGLPNG 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rnf145	NP_083138.2	TRC8_N	8..506	CDD:463960	57/292 (20%)
		YLYF motif. /evidence=ECO:0000269|PubMed:29374057	81..84
		HRD1	<520..627	CDD:227568	40/114 (35%)
		RING-H2_RNF145	533..575	CDD:319598	18/42 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	587..663		19/72 (26%)
sip3	NP_651894.3	HRD1	20..>365	CDD:227568	94/403 (23%)