DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rnf145 and Trc8

DIOPT Version :9

Sequence 1:	NP_001350095.1	Gene:	Rnf145 / 74315	MGIID:	1921565	Length:	663	Species:	Mus musculus
Sequence 2:	NP_996303.1	Gene:	Trc8 / 43476	FlyBaseID:	FBgn0039668	Length:	809	Species:	Drosophila melanogaster

Alignment Length:	784	Identity:	212/784 - (27%)
Similarity:	346/784 - (44%)	Gaps:	175/784 - (22%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MAAKEKLEAVLNVALRVPSIMLLDVLYRWDV---------------------------------- 31
            |:.:.|:..:::|.:|||.:|::|.:.:.|:
  Fly     1 MSVRTKVLGLVDVMMRVPPVMVIDEILKMDMGMQSWLYPDKDKASGALATPTEAPAVPSGQDPFT 65

Mouse    32 --------------SSFFQQIQRSS------------LNN--NPLFQYKYLA--LNMHYVGYILS 66
                          |...|.|:::|            .|:  |.|.:.:.||  |:...|.::|.
  Fly    66 SIKELFSHMTTSAQSVLEQSIEKASEAAKTHGMLSSGFNSLMNELSKDQTLADVLSTTTVKFVLC 130

Mouse    67 V-------VLLTLPRQHLVQLYLYFVTALLLYAGHQISRDYVRSELESAYEGPMYLEPL-SMNRF 123
            |       .:..|..:|||.:|::..:..|.:..:..:    .|.|......|..:|.| |:|
  Fly   131 VFAFLSAACIFMLWTRHLVMVYMFLTSLGLTFLSYWSN----VSALALTERSPSMVEDLMSLN-- 189

Mouse   124 TTALIGQ-LVVCTLCSCVMKTKQIWLFSAH-------------------------MLPLLAR--- 159
            ||.|:.. .||.:|...:|....:.:..|:                         ||||.|:
  Fly   190 TTRLLDSGGVVMSLAPHLMAQWFMGMLFAYIHLGPRFEHVQRSMPIIFASPILLAMLPLPAKVVQ 254

Mouse   160 -LCLVPLETIVIINKFAMIFTGLEVLYFLGSNLLVPYNLAKSAYRELVQVVEVYGLLALGMSLWN 223
             |.:|.:.|.:|:.|..::.:.:|....:       ||    .|:..:..|..:||.||..:.|.
  Fly   255 HLPVVAVFTPIILTKITLMQSAMEASRTV-------YN----GYQYAMNFVSNFGLSALIENEWQ 308

Mouse   224 QLVVPVLFMVFWLVLFALQIYSYFSTR-DQP----ASRERLLFLFLTSIAECCSTPYSLLGLVFT 283
            :|.||.:..|||.:......|:..:|. |:|    .:.::||       .:.|.|..::||:.
  Fly   309 RLNVPNVLRVFWTIRLIQGGYALATTESDEPLDLMTATQKLL-------VDGCETMTAVLGMT-- 364

Mouse   284 VSFVALGVLTL-CKFYLQGYRAFM---NDPAMNRGMTEGVTLLILAVQTGLIELQVVHRAFLLSI 344
                  ||::: |.:..:|::.::   :|...:.|....|...|||:||||..|....|...|..
  Fly   365 ------GVISMFCHYIGRGFQWYLLTYDDEEKSLGTVSAVLFYILALQTGLTSLSPDKRFIRLCR 423

Mouse   345 ILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVFPAYMAYMICQFFHMDFW 409
            .|.:::.::|..:..|..||:::|.|:|:.|..:|.||:|:|.||:|....:.|.:.....:..|
  Fly   424 NLCLLMTALLHFLHNIVSPILMSLSAARNPSRKRHVRALSVCAFLVVLSVSLLYHLWSQQSISTW 488

Mouse   410 LLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVNGTYRLLEFVVALCVVAYGV 474
            ||.:.:.|:...::||.:|..|.||:::..|:...|.:||.:|||......:||       .:|:
  Fly   489 LLAVTAFSVEVVVKVLVSLATYTLFLLDARRQFFWEKLDDYLYYVRAFGNSVEF-------CFGI 546

Mouse   475 SETIFGEWTV------------MGSMIIFIHSYYNVWLRAQLGWKSFLLRRDAVNKIKSLPVATQ 527
            ...|.|.|.:            :.::::.||:|:|:|..|:.||..|:.||.||:||.:||.||.
  Fly   547 LLFINGAWILIFESAQNATGGGIRAIMMCIHAYFNIWCEARAGWSVFMKRRSAVHKISALPEATP 611

Mouse   528 EQLEKHNDICAICYQDMKSAVITPCSHFFHAGCLKKWLYVQDTCPLCHCHLKNSSQLPGLGTEAA 592
            .||:..:|:||||||:|.||.||.|.||||..||:|||||||.|||||..:..:.:......||.
  Fly   612 AQLQAFDDVCAICYQEMYSAKITRCRHFFHGVCLRKWLYVQDRCPLCHEIMMYTDKADENAPEAE 676

Mouse   593 PQPPAGAEQ-----------NIVLQ-EGPE-PPDHESPPGTGTQEGSGDSSEHINRGSASQEGAA 644
            |.|.|.|||           |...| ..|| .|...|.....|...|..::......||..|.||
  Fly   677 PAPAAQAEQPMRIYPRDDANNAAAQRRSPERAPVEASEQAPATSSSSAAATIGAEAVSAIVESAA 741

Mouse   645 DAGE 648
            ..||
  Fly   742 AVGE 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf145	NP_001350095.1	TRC8_N	8..506	CDD:372682	141/620 (23%)
		YLYF motif. /evidence=ECO:0000269\|PubMed:29374057	81..84		1/2 (50%)
		HRD1	<520..627	CDD:227568	52/119 (44%)
		RING-H2_RNF145	533..575	CDD:319598	29/41 (71%)
		RING-H2 finger (C3H2C3-type)	537..574	CDD:319598	27/36 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..663		23/75 (31%)
Trc8	NP_996303.1	TRC8_N	122..590	CDD:290425	124/506 (25%)
		zf-rbx1	<618..659	CDD:289448	29/40 (73%)
		zf-RING_2	619..659	CDD:290367	29/39 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	73	1.000	Domainoid score	I9245
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D897451at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820