DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rnf145 and hrd1

DIOPT Version :9

Sequence 1:	NP_001350095.1	Gene:	Rnf145 / 74315	MGIID:	1921565	Length:	663	Species:	Mus musculus
Sequence 2:	NP_596376.1	Gene:	hrd1 / 2539900	PomBaseID:	SPBC17D11.02c	Length:	677	Species:	Schizosaccharomyces pombe

Alignment Length:	505	Identity:	98/505 - (19%)
Similarity:	181/505 - (35%)	Gaps:	177/505 - (35%)

- Green bases have known domain annotations that are detailed below.

Mouse   229 VLFMVFWLVLFALQIYSYFSTRDQPASRERLLFLFLTSIAECCSTPYSLLGLVF-TVSFVALGV- 291
            :|:::..||||.|.:               ||.|:.:      :..||...::. :...:.:|:
pombe     4 ILYVLASLVLFGLSV---------------LLSLYSS------ANVYSATVMISQSPVHITIGLN 47

Mouse   292 LTLCKFYLQGYRAFMNDPAMNRGMTEGVTLLILAVQTGLIELQVVHRAFLLSIILFIVVASILQS 356
            :.||.|:     |..|  |:.       |||..::||  .||::::..|.:::
pombe    48 VCLCLFF-----AIAN--ALK-------TLLFGSLQT--FELELLYEQFWITL------------ 84

Mouse   357 MLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVFPAYMAYMICQF-------------FHM-- 406
                 ..|:||:...|:......|..:|..:|..||     :.||.|             ||:
pombe    85 -----TEIMLAITVFREAISISFFMLLSTLMFARVF-----HSICSFRTERLQIQLTDQRFHIFS 139

Mouse   407 ----DFWLLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVNGTYRLLEFVV-- 465
                .:::|.|:.:|:           ||:.|..|....:...    :::....:..||...:
pombe   140 RLTCAYFVLSILDASL-----------IYLCFTSEHLGDKSTR----MLFVCEFSVLLLNLTIEA 189

Mouse   466 -ALCVVAYGVS--ETIFGEWT--------------VMGSMIIFIHS-----------------YY 496
             .||:..|...  :.::.|.:              ::...::|::.                 :|
pombe   190 SKLCIYLYEARHLDQVWDEKSTYLFRLEVCRDGLRLLAYSLLFMYQFPYVSVPIYSIRQMYTCFY 254

Mouse   497 NVWLRAQLGWKSFLLRRDAVNKIKSL-PVATQEQLEKHNDICAICYQDM---------------- 544
            :::.|.    :.....|.|...:.:: |.||:|||...:..|.||.::|
pombe   255 SLFRRI----REHARFRQATRDMNAMYPTATEEQLTNSDRTCTICREEMFHPDHPPENTDEMEPL 315

Mouse   545 -KSAVIT----PCSHFFHAGCLKKWLYVQDTCPLCHCHLKNSSQLPGLGTEAAP-----QPPAGA 599
             :...:|    ||.|..|..||:.||..|.|||:|...:        :|.:::|     .|...|
pombe   316 PRGLDMTPKRLPCGHILHFHCLRNWLERQQTCPICRRSV--------IGNQSSPTGIPASPNVRA 372

Mouse   600 EQNIVLQEGPEP---PDHESPPGTGTQEGSGDSSEHINRG--SASQEGAA 644
            .|  :..:.|.|   |...:.||.......||.......|  :|:..|.|
pombe   373 TQ--IATQVPNPQNTPTTTAVPGITNSSNQGDPQASTFNGVPNANSSGFA 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf145	NP_001350095.1	TRC8_N	8..506	CDD:372682	56/333 (17%)
		YLYF motif. /evidence=ECO:0000269\|PubMed:29374057	81..84
		HRD1	<520..627	CDD:227568	34/136 (25%)
		RING-H2_RNF145	533..575	CDD:319598	17/62 (27%)
		RING-H2 finger (C3H2C3-type)	537..574	CDD:319598	17/57 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..663		16/68 (24%)
hrd1	NP_596376.1	HRD1	1..514	CDD:227568	98/505 (19%)
hrd1	NP_596376.1	zf-RING_2	291..351	CDD:290367	17/59 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770