Protein Alignment Rnf145 and hrd1

DIOPT Version :10

• Sequence 1: NP_083138.2
• Gene: Rnf145 / 74315
• MGIID: 1921565
• Length: 663
• Species: Mus musculus
• Sequence 2: NP_596376.1
• Gene: hrd1 / 2539900
• PomBaseID: SPBC17D11.02C
• Length: 677
• Species: Schizosaccharomyces pombe
• Alignment Length: 505
• Identity: 98/505 - (19%)
• Similarity: 181/505 - (35%)
• Gaps: 177/505 - (35%)

Mouse   229 VLFMVFWLVLFALQIYSYFSTRDQPASRERLLFLFLTSIAECCSTPYSLLGLVF-TVSFVALGV- 291
            :|:::..||||.|.:               ||.|:.:      :..||...::. :...:.:|:
pombe     4 ILYVLASLVLFGLSV---------------LLSLYSS------ANVYSATVMISQSPVHITIGLN 47

Mouse   292 LTLCKFYLQGYRAFMNDPAMNRGMTEGVTLLILAVQTGLIELQVVHRAFLLSIILFIVVASILQS 356
            :.||.|:     |..|  |:.       |||..::||  .||::::..|.:::
pombe    48 VCLCLFF-----AIAN--ALK-------TLLFGSLQT--FELELLYEQFWITL------------ 84

Mouse   357 MLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVFPAYMAYMICQF-------------FHM-- 406
                 ..|:||:...|:......|..:|..:|..||     :.||.|             ||:
pombe    85 -----TEIMLAITVFREAISISFFMLLSTLMFARVF-----HSICSFRTERLQIQLTDQRFHIFS 139

Mouse   407 ----DFWLLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVNGTYRLLEFVV-- 465
                .:::|.|:.:|:           ||:.|..|....:...    :::....:..||...:
pombe   140 RLTCAYFVLSILDASL-----------IYLCFTSEHLGDKSTR----MLFVCEFSVLLLNLTIEA 189

Mouse   466 -ALCVVAYGVS--ETIFGEWT--------------VMGSMIIFIHS-----------------YY 496
             .||:..|...  :.::.|.:              ::...::|::.                 :|
pombe   190 SKLCIYLYEARHLDQVWDEKSTYLFRLEVCRDGLRLLAYSLLFMYQFPYVSVPIYSIRQMYTCFY 254

Mouse   497 NVWLRAQLGWKSFLLRRDAVNKIKSL-PVATQEQLEKHNDICAICYQDM---------------- 544
            :::.|.    :.....|.|...:.:: |.||:|||...:..|.||.::|
pombe   255 SLFRRI----REHARFRQATRDMNAMYPTATEEQLTNSDRTCTICREEMFHPDHPPENTDEMEPL 315

Mouse   545 -KSAVIT----PCSHFFHAGCLKKWLYVQDTCPLCHCHLKNSSQLPGLGTEAAP-----QPPAGA 599
             :...:|    ||.|..|..||:.||..|.|||:|...:        :|.:::|     .|...|
pombe   316 PRGLDMTPKRLPCGHILHFHCLRNWLERQQTCPICRRSV--------IGNQSSPTGIPASPNVRA 372

Mouse   600 EQNIVLQEGPEP---PDHESPPGTGTQEGSGDSSEHINRG--SASQEGAA 644
            .|  :..:.|.|   |...:.||.......||.......|  :|:..|.|
pombe   373 TQ--IATQVPNPQNTPTTTAVPGITNSSNQGDPQASTFNGVPNANSSGFA 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rnf145	NP_083138.2	TRC8_N	8..506	CDD:463960	56/333 (17%)
		YLYF motif. /evidence=ECO:0000269|PubMed:29374057	81..84
		HRD1	<520..627	CDD:227568	34/136 (25%)
		RING-H2_RNF145	533..575	CDD:319598	17/62 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	587..663		16/68 (24%)
hrd1	NP_596376.1	HRD1	1..514	CDD:227568	98/505 (19%)
		PRK08581	455..>669	CDD:236304