Protein Alignment EZR and Mer

DIOPT Version :10

• Sequence 1: NP_003370.2
• Gene: EZR / 7430
• HGNCID: 12691
• Length: 586
• Species: Homo sapiens
• Sequence 2: NP_523413.1
• Gene: Mer / 32979
• FlyBaseID: FBgn0086384
• Length: 635
• Species: Drosophila melanogaster
• Alignment Length: 640
• Identity: 268/640 - (41%)
• Similarity: 381/640 - (59%)
• Gaps: 70/640 - (10%)

Human     3 KPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSA 67
            :.::|||:|.|:||||.::|..:|:.|||.|.:||||||.|||||.|||.:...:|||::|:|..
  Fly    10 RSLSVRVSTFDSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKRVRD 74

Human    68 QEVR---KENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYA 129
            |.|.   ..|...|.|.|||:||:|:|||||:|||.|||||||:.|||.:|||.||.:|||.|||
  Fly    75 QRVELHASNNVYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLASYA 139

Human   130 VQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKI 194
            |..::|.|:.|.:|.|.|:...|:|:.|.||:::|.:.||:||:.|:.:|..|.:|...:|||||
  Fly   140 VHVQYGPYDYETYKDGMLAGGELLPKGVTDQYQMTPEMWEERIKTWYMDHEPMTRDEVEMEYLKI 204

Human   195 AQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKP 259
            ||||:|||:|||.|.||..|.|||||.::|||||::.||||||..|.|:|||::||:||||.|:.
  Fly   205 AQDLDMYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFTIRL 269

Human   260 IDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLE 324
            :|.|..:|:||:..|.|||.||.||.|||:||||||||||:|:|||||||:|||.::|:||::..
  Fly   270 VDAKVSNFIFYSQDLHINKMILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKEEKQRRQIERKKFI 334

Human   325 TEKKRRETVEREKEQMMREKEELM--LRLQD----YEEKTKKAERELSEQIQRALQLEE-ERKRA 382
            .|||.||..|.|:.::.:..|.|.  :|:.:    ..|:||:...|.|...:..:||.| :....
  Fly   335 REKKLREKAEHERYELEKSMEHLQNEMRMANDALRRSEETKELYFEKSRVNEEQMQLTECKANHF 399

Human   383 QEEAERLEADRMAALRAKEELE-------------------RQAVDQIKSQEQLAAELAEYTAKI 428
            :.|.:||...:|...|.|.:||                   |:|..:...:|.:.|::||..|..
  Fly   400 KTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDKREAETEKLRKELICAKMAEREATA 464

Human   429 ALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQD-- 491
            .|||.....:           |.:.|.|:......|...||  .....:..| |.....|..|
  Fly   465 RLLEFLNSGR-----------KSSTDSLLTASSVSHAANTA--SSMAAISTP-SLITSSSTNDLE 515

Human   492 --EGAEPTGYSAEL-----SSEGIRDD---------RNEEKRIT-EAEKN--------ERVQRQL 531
              .|||.|.:|:..     :|.||.||         .||.::|| |.|:|        ::||.||
  Fly   516 TAGGAELTTHSSHYLVQGDNSSGISDDFEPKEFILTDNEMEQITNEMERNHLDYLRNSKQVQSQL 580

Human   532 LTLSSELSQARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL 586
            .||.||::..:.|..:::.||:....::.|.:||.||::::.|:||.|:..||.|
  Fly   581 QTLRSEIAPHKIEENQSNLDILSEAQIKAGENKYSTLKKLKSGSTKARVAFFEEL 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EZR	NP_003370.2	B41	7..206	CDD:214604	108/201 (54%)
		[IL]-x-C-x-x-[DE] motif. /evidence=ECO:0000305|PubMed:25417112	115..120		3/4 (75%)
		FERM_C_ERM	200..296	CDD:270015	59/95 (62%)
		Interaction with SCYL3. /evidence=ECO:0000269|PubMed:12651155	244..586		135/394 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	306..341		17/34 (50%)
		ERM_helical	337..456	CDD:466641	31/144 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	485..564		31/105 (30%)
		ERM_C	510..586	CDD:459932	31/93 (33%)
Mer	NP_523413.1	B41	14..216	CDD:214604	108/201 (54%)
		FERM_C_ERM	210..306	CDD:270015	59/95 (62%)
		ERM_helical	340..459	CDD:466641	27/118 (23%)
		ERM_C	559..635	CDD:459932	26/75 (35%)