Protein Alignment VIL1 and qua

DIOPT Version :10

• Sequence 1: NP_009058.2
• Gene: VIL1 / 7429
• HGNCID: 12690
• Length: 827
• Species: Homo sapiens
• Sequence 2: NP_001246066.1
• Gene: qua / 35058
• FlyBaseID: FBgn0003187
• Length: 892
• Species: Drosophila melanogaster
• Alignment Length: 905
• Identity: 245/905 - (27%)
• Similarity: 402/905 - (44%)
• Gaps: 148/905 - (16%)

Human    21 IWRIEAMQMVPVPSSTFGSFFDGDCYIILAI--------HKTAS-------SLSYDIHYWIGQDS 70
            ||:|:..::..|..|.:|:|:|...|||.|.        |:|.:       ||...||||:|::.
  Fly    38 IWKIDEDRLEAVQRSHYGTFYDSCAYIIYAASLSGHYANHETITREQKPNVSLERYIHYWLGKNV 102

Human    71 SLDEQGAAAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQG----LVIRKGGVASGMKHVET 131
            |...:........::|.:|...:..:||.|..||..|..|||:|    ..:|.|.:.|..:.
  Fly   103 SEQNRSNVVHKIQELDSYLGNISSIYRETQNLESARFLSYFKKGYEFRFSVRSGALISAPQR--- 164

Human   132 NSYDVQRLLHVKGKRNVVAGEV-EMSWKSFNRGDVFLLDLGKLIIQWNGPESTRMERLRGMTLAK 195
                 .||..:..::.:.:.|| .:.|..||...|.:|....|...|.|..|:.:||...:...:
  Fly   165 -----PRLFQLYARKWLRSIEVATIDWSHFNSDYVMVLQTDNLTYVWIGRSSSGIERRSALDWVQ 224

Human   196 EIRDQERGGRTYVGVVDGENELASPKLMEVMNHVLGKRRELKAAVPDTVVEPALKAALKL-YHVS 259
                :...|.....|.||..:..|.:..|:.|.:|..::.:.......|.|.|...:.|. .:..
  Fly   225 ----KHCSGSPITIVDDGYEQAMSQEHKELWNTMLPLKKRMVCQASQLVSEYADYNSNKFRIYKC 285

Human   260 DSEGNLVVREV-ATRPLTQDLLSHEDCYILDQGGLKIYVWKGKKANEQEKKGAMSHALNFIKAKQ 323
            :..|.|.:.:: ...|...||......|:||..|..|::|.|.:|.:.:...||.:...|:|.|:
  Fly   286 NQRGRLHLDQLDVGMPAKDDLSDAHGVYLLDNYGQSIWLWVGGQAPQADALSAMGNGRAFVKKKK 350

Human   324 YPPSTQVEVQNDGAESAVFQQLFQKWTASNRTSGLGKTHTVGSVAKVEQVKF---DATSMHVKPQ 385
            ||.:|.|....:|.|...|::||..|.      .:.:.:|.|.  |....||   ||.|:..:|:
  Fly   351 YPDNTLVVRVLEGHEPVEFKRLFANWL------NVWQENTRGH--KPVSTKFGKLDAHSLCERPK 407

Human   386 VAAQQKMVDDGSGEVQVWRI--ENLELVPVDSKWL-----GHF---YGGDCYLLLYTYLIGEKQH 440
            :||..::||||.||..::|:  :.::.||: ||.:     ..|   |...|..::...|......
  Fly   408 MAADTQLVDDGRGERVIYRVFGDQVQEVPI-SKTVVFTTNASFVVKYSVQCATVVPADLASVGIK 471

Human   441 YLLYVWQGSQASQDEITASAYQAVILDQKYNG--EP-VQIRVPMGKEPPHLMSIFKGRMVVYQGG 502
            .::|.|.||:||.:.|:.:...|   ...::|  || :.:::....||||.:.||:|::::.:|
  Fly   472 TIIYQWNGSEASVESISRADKFA---KASFDGLKEPGMFVQLYEFDEPPHFLQIFEGKLIIRRG- 532

Human   503 TSRTNNLETGPS-----TRLFQVQGTGANNTKAFEVPARANFLNSNDVFVLKTQSCCYLWCGKGC 562
             .||.....|.|     |.|.:|.|..:.|.||.| ....:.::|.|.:|:||.. .::|||:..
  Fly   533 -QRTEMPYNGNSNALLDTFLLKVYGDASYNAKAVE-ETHLSSISSKDCYVIKTNH-VWVWCGQSS 594

Human   563 SGDEREMAKMVADTISRTEKQVVVEGQEPANFWMALGGKAPYANTKRLQEENLVITPRLFECSNK 627
            :||.|||||.|...:.  |..:|:||:|...||.::   |.|.|      :.|||......||:.
  Fly   595 TGDAREMAKAVGALMG--ENSLVLEGKESKEFWQSV---AMYFN------QTLVINGNGNSCSSS 648

Human   628 TGR-------------------------FLATEIPD-------------------------FNQD 642
            |..                         :|.|.:|.                         |:|.
  Fly   649 TSSSSGAGSMCNGSSNGGNISPTLSNNCYLNTSVPSKPRPPVQLFLVWWQQSSLRYEEILGFDQQ 713

Human   643 DLEEDDVFLLDVWDQVFFWIGKHANEEEKKAAATTAQEYLKTHPSGRDPETPIIVVKQGHEPPTF 707
            ||..|..::||.....:.|:|..|..:|:..|  .||.|::..|.||...|.:.||:|..||..|
  Fly   714 DLSSDCTYILDTGSLTYVWLGSQAPNQERYTA--IAQSYVQNAPFGRRSATALAVVRQFQEPNVF 776

Human   708 TGWFLAWDPFKWSNTKSYEDLKAELGNSRD-----WSQITAEVTSPKVDVFNANSNLSSGPLPIF 767
            .|:|.:|......|..|||.::.:|||...     .|:.:|.:.:.:...|:.:..        :
  Fly   777 KGFFESWQNDYGKNFHSYEKMRKDLGNKVTSNCCFASEGSALILNNRQKDFDGHKK--------Y 833

Human   768 PLEQLVNKPVEELPEGVDPSRKEEHLSIEDFTQAFGMTPAAFSALPRWKQQNLKKEKGLF 827
            ||..|:.: ::.||..::|.::|.||:.:||...|.|:...|..||:||:..|||:..||
  Fly   834 PLTVLIQE-MDMLPPDINPLKREVHLTHDDFVSVFNMSFYEFDELPKWKKMELKKQFKLF 892

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VIL1	NP_009058.2	Core	2..734		217/805 (27%)
		Necessary for homodimerization	2..126		37/123 (30%)
		gelsolin_S1_like	17..121	CDD:200446	35/118 (30%)
		LPA/PIP2-binding site 1	112..119		2/10 (20%)
		gelsolin_S2_like	136..225	CDD:200445	20/89 (22%)
		LPA/PIP2-binding site 2	138..146		2/7 (29%)
		gelsolin_S3_like	250..348	CDD:200448	28/99 (28%)
		gelsolin_S4_like	392..492	CDD:200449	30/112 (27%)
		gelsolin_S5_like	513..603	CDD:200444	32/94 (34%)
		gelsolin_S6_like	619..715	CDD:200447	33/145 (23%)
		Headpiece	735..827		24/96 (25%)
		VHP	792..827	CDD:460493	14/34 (41%)
		LPA/PIP2-binding site 3	816..824		4/7 (57%)
qua	NP_001246066.1	ADF_gelsolin	26..147	CDD:472830	33/108 (31%)
		gelsolin_like	164..254	CDD:200436	22/101 (22%)
		gelsolin_S3_like	276..375	CDD:200448	28/98 (29%)
		GEL	424..526	CDD:214590	26/105 (25%)
		ADF_gelsolin	551..625	CDD:472830	28/77 (36%)
		gelsolin_like	689..780	CDD:200436	26/92 (28%)
		VHP	857..892	CDD:128458	14/34 (41%)