DRSC/TRiP Functional Genomics Resources

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Protein Alignment VHL and ERJ5

DIOPT Version :10

Sequence 1:NP_000542.1 Gene:VHL / 7428 HGNCID:12687 Length:213 Species:Homo sapiens
Sequence 2:NP_116699.3 Gene:ERJ5 / 850602 SGDID:S000001937 Length:295 Species:Saccharomyces cerevisiae


Alignment Length:143 Identity:28/143 - (19%)
Similarity:54/143 - (37%) Gaps:48/143 - (33%)


- Green bases have known domain annotations that are detailed below.


Human     4 RAENW--------DEAEVGAEEAGVEEYGPEEDGGEESGAEESG---PEESGPEELGAEEEMEAG 57
            |.||:        |...:|.::...:::  |:|.|:......|.   .|..|.|.|.:.:.::  
Yeast   160 RIENFISQCKQQDDTNGLGVKQLTFKQH--EKDEGKSLVVRFSDVYVVEPDGSETLISPDTLD-- 220

Human    58 RPRPVLRSVNSREPSQVIFCNRSPRVVLPVW-LNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRD 121
              :|.:::        .:|.    |:...|| :.|              |:.:.| .|...:..|
Yeast   221 --KPSVKN--------CLFW----RIPASVWNMTF--------------GKSVGS-AGKEEIITD 256

Human   122 AGTHDGLLVNQTE 134
            :..:||   |||:
Yeast   257 SKKYDG---NQTK 266

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VHLNP_000542.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..65 14/71 (20%)
8 X 5 AA tandem repeats of G-[PAVG]-E-E-[DAYSLE] 14..53 9/41 (22%)
VHL 63..144 CDD:460360 14/73 (19%)
Involved in binding to CCT complex 100..155 9/35 (26%)
VHL_C 156..204 CDD:407332
Interaction with Elongin BC complex 157..166
ERJ5NP_116699.3 DnaJ 44..105 CDD:395170
Blue background indicates that the domain is not in the aligned region.

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