Protein Alignment VHL and vhl

DIOPT Version :10

• Sequence 1: NP_000542.1
• Gene: VHL / 7428
• HGNCID: 12687
• Length: 213
• Species: Homo sapiens
• Sequence 2: NP_001074153.1
• Gene: vhl / 791202
• ZFINID: ZDB-GENE-070112-1042
• Length: 175
• Species: Danio rerio
• Alignment Length: 153
• Identity: 80/153 - (52%)
• Similarity: 108/153 - (70%)
• Gaps: 0/153 - (0%)

Human    51 EEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGH 115
            ::..|..:|.|::||:.||....|:|||.|||||.|||:||.||||||..:.|.|||||.::.||
Zfish     3 QDSQEGQQPLPLVRSLISRIQVNVLFCNCSPRVVKPVWINFLGEPQPYVNIQPYTGRRITTFVGH 67

Human   116 LWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDI 180
            .|:||||.|.|.::||..|:::|:...:||...|.|||||.||::|||||||.||:.|:..||:|
Zfish    68 PWMFRDAETDDPMVVNNKEMYLPASLENGQVANAKITLPVLTLRDRCLQVVRRLVRREDVGRLEI 132

Human   181 VRSLYEDLEDHPNVQKDLERLTQ 203
            .|.|.|||...|::|.||.|::|
Zfish   133 ARCLQEDLAQRPSIQADLRRISQ 155

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VHL	NP_000542.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..65		3/13 (23%)
		8 X 5 AA tandem repeats of G-[PAVG]-E-E-[DAYSLE]	14..53		0/1 (0%)
		VHL	63..144	CDD:460360	43/80 (54%)
		Involved in binding to CCT complex	100..155		25/54 (46%)
		VHL_C	156..204	CDD:407332	26/48 (54%)
		Interaction with Elongin BC complex	157..166		6/8 (75%)
vhl	NP_001074153.1	VHL	15..96	CDD:460360	43/80 (54%)
		VHL_C	108..156	CDD:407332	26/48 (54%)