DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VHL and Vhl

DIOPT Version :9

Sequence 1:	NP_000542.1	Gene:	VHL / 7428	HGNCID:	12687	Length:	213	Species:	Homo sapiens
Sequence 2:	NP_001260885.1	Gene:	Vhl / 53433	FlyBaseID:	FBgn0041174	Length:	178	Species:	Drosophila melanogaster

Alignment Length:	138	Identity:	35/138 - (25%)
Similarity:	58/138 - (42%)	Gaps:	30/138 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    67 NSREPSQ------------VIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLF 119
            |:|:..|            |:|.|.:.|.:...|:........|.||.|....|::::..|.|||
  Fly     8 NNRDGQQLVGADQGKVEVYVLFANTTYRTLDLYWVCERERENMYLTLKPFEEVRVNTFTTHSWLF 72

Human   120 RDAGTHDGLLVNQTELFVP--------------SLNVDGQPIFANITLPVYTLKERCLQVV-RSL 169
            ||..|.:.:.|....:|.|              .::|..:.:   |..|:.:|:|.||.:| |.|
  Fly    73 RDYYTGERMHVRSQRIFQPIRVRVPKSQQSPDQLVDVRSEVL---IHFPMRSLRENCLWLVARWL 134

Human   170 VKPENYRR 177
            ::..|..|
  Fly   135 IRTSNAPR 142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VHL	NP_000542.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..65
		Trypan_PARP	<7..86	CDD:330686	7/30 (23%)
		8 X 5 AA tandem repeats of G-[PAVG]-E-E-[DAYSLE]	14..53
		pVHL	64..203	CDD:176472	35/138 (25%)
		Involved in binding to CCT complex	100..155		16/68 (24%)
		Interaction with Elongin BC complex	157..166		4/8 (50%)
Vhl	NP_001260885.1	pVHL	21..162	CDD:176472	32/125 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159728
Domainoid	1	1.000	42	1.000	Domainoid score	I12433
eggNOG	1	0.900	-	-		E1_KOG4710
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005700
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_107013
Panther	1	1.100	-	-	LDO	PTHR15160
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9301
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.730