Protein Alignment VHL and Vhl

DIOPT Version :10

• Sequence 1: NP_000542.1
• Gene: VHL / 7428
• HGNCID: 12687
• Length: 213
• Species: Homo sapiens
• Sequence 2: NP_434688.1
• Gene: Vhl / 24874
• RGDID: 3960
• Length: 185
• Species: Rattus norvegicus
• Alignment Length: 176
• Identity: 154/176 - (87%)
• Similarity: 166/176 - (94%)
• Gaps: 2/176 - (1%)

Human    38 SGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLP 102
            :.|||:  |.:...||:||||||||||||||||||||||||||||||||:|||||||||||||||
  Rat     6 ASPEEA--ERMPGSEEIEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPLWLNFDGEPQPYPTLP 68

Human   103 PGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVR 167
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    69 PGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVR 133

Human   168 SLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD 213
            |||||||||||||||||||||||||||:||::|||||.:.:|.:|:
  Rat   134 SLVKPENYRRLDIVRSLYEDLEDHPNVRKDIQRLTQEHLENQALGE 179

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VHL	NP_000542.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..65		15/26 (58%)
		8 X 5 AA tandem repeats of G-[PAVG]-E-E-[DAYSLE]	14..53		4/14 (29%)
		VHL	63..144	CDD:460360	79/80 (99%)
		Involved in binding to CCT complex	100..155		54/54 (100%)
		VHL_C	156..204	CDD:407332	44/47 (94%)
		Interaction with Elongin BC complex	157..166		8/8 (100%)
Vhl	NP_434688.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		13/24 (54%)
		VHL	29..110	CDD:460360	79/80 (99%)
		VHL_C	122..170	CDD:407332	44/47 (94%)
		Interaction with Elongin BC complex. /evidence=ECO:0000250	123..132		8/8 (100%)