Protein Alignment VHL and Vhl

DIOPT Version :10

• Sequence 1: NP_000542.1
• Gene: VHL / 7428
• HGNCID: 12687
• Length: 213
• Species: Homo sapiens
• Sequence 2: NP_033533.1
• Gene: Vhl / 22346
• MGIID: 103223
• Length: 181
• Species: Mus musculus
• Alignment Length: 211
• Identity: 157/211 - (74%)
• Similarity: 168/211 - (79%)
• Gaps: 34/211 - (16%)

Human     1 MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRS 65
            |||:|.:                 |||..|           |.||      ||||||||||||||
Mouse     1 MPRKAAS-----------------PEEAAG-----------EPGP------EEMEAGRPRPVLRS 31

Human    66 VNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLV 130
            |||||||||||||||||||||:||||||||||||.||||||||||||||||||||||||||||||
Mouse    32 VNSREPSQVIFCNRSPRVVLPLWLNFDGEPQPYPILPPGTGRRIHSYRGHLWLFRDAGTHDGLLV 96

Human   131 NQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQ 195
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|:|:
Mouse    97 NQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDYPSVR 161

Human   196 KDLERLTQERIAHQRM 211
            ||::||:||.:..|.:
Mouse   162 KDIQRLSQEHLESQHL 177

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VHL	NP_000542.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..65		23/63 (37%)
		8 X 5 AA tandem repeats of G-[PAVG]-E-E-[DAYSLE]	14..53		7/38 (18%)
		VHL	63..144	CDD:460360	78/80 (98%)
		Involved in binding to CCT complex	100..155		53/54 (98%)
		VHL_C	156..204	CDD:407332	41/47 (87%)
		Interaction with Elongin BC complex	157..166		8/8 (100%)
Vhl	NP_033533.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		22/62 (35%)
		VHL	29..110	CDD:460360	78/80 (98%)
		VHL_C	122..170	CDD:407332	41/47 (87%)
		Interaction with Elongin BC complex. /evidence=ECO:0000250	123..132		8/8 (100%)