DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment VDR and EcR

DIOPT Version :9

Sequence 1:NP_001351014.1 Gene:VDR / 7421 HGNCID:12679 Length:494 Species:Homo sapiens
Sequence 2:NP_001163061.1 Gene:EcR / 35540 FlyBaseID:FBgn0000546 Length:878 Species:Drosophila melanogaster


Alignment Length:571 Identity:156/571 - (27%)
Similarity:237/571 - (41%) Gaps:117/571 - (20%)


- Green bases have known domain annotations that are detailed below.


Human     2 EAMAASTSLPDPGDFDRNVPRI----CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPF 62
            |:..|..|...|      .||:    |.||||||:|:|:||:||||||||||||:.:.|::.|.|
  Fly   244 ESCDAKKSKKGP------APRVQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKF 302

Human    63 NGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEE 127
            ...|.:....||.||.||||:|:.:||..|.::.:.:...||    :.|:.:..||.:....|.:
  Fly   303 GRACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAMKR----REKKAQKEKDKMTTSPSSQ 363

Human   128 QQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRP----------NSRHTPSFSGDS 182
            .....::..............|.....||        .|.:.|          .:|:.||.:.:.
  Fly   364 HGGNGSLASGGGQDFVKKEILDLMTCEPP--------QHATIPLLPDEILAKCQARNIPSLTYNQ 420

Human   183 SSSCSDHCITSSDMMDSSSFSNLD--LSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFA 245
            .:... ..|...|..:..|..:|.  :|:.|.::....:...      |:.::...::|.::.||
  Fly   421 LAVIY-KLIWYQDGYEQPSEEDLRRIMSQPDENESQTDVSFR------HITEITILTVQLIVEFA 478

Human   246 KMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFT-MDDMSWTCGNQDYKYRVSDVTKAGHSLEL 309
            |.:|.|..:..||||.|||:.:.||:|||....:. ..|..:...|:.|   ..|..|.....:.
  Fly   479 KGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSY---TRDSYKMAGMADN 540

Human   310 IEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPP 374
            ||.|:.|...:..:.:...|:.||.||.|.| ||||::.|.|:||||....:||:.||..||...
  Fly   541 IEDLLHFCRQMFSMKVDNVEYALLTAIVIFS-DRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGD 604

Human   375 GSHLL-YAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGNEI------------ 426
            ...|: |||::..|.:||:|..::::.  |.      |:||....|..|..||            
  Fly   605 SMSLVFYAKLLSILTELRTLGNQNAEM--CF------SLKLKNRKLPKFLEEIWDVHAIPPSVQS 661

Human   427 -------------------SXLGQPVAVPGWGCSSRATCQARGWRLLSSPPHPVWGSA------- 465
                               : :|..:.. |..|.|.:|..|.........|.|....:       
  Fly   662 HLQITQEENERLERAERMRASVGGAITA-GIDCDSASTSAAAAAAQHQPQPQPQPQPSSLTQNDS 725

Human   466 ---------PPLPPPL--STQPILSP---------VQPNP--FPAGFSPVP 494
                     |.|||.|  ..||.|.|         :||.|  .|.. :|||
  Fly   726 QHQTQPQLQPQLPPQLQGQLQPQLQPQLQTQLQPQIQPQPQLLPVS-APVP 775

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VDRNP_001351014.1 NR_DBD_VDR 16..122 CDD:143513 46/109 (42%)
Hinge 97..126 5/28 (18%)
NR_LBD_VDR 124..426 CDD:132731 80/315 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 158..190 5/41 (12%)
Vitamin D3 binding 227..237 1/9 (11%)
Vitamin D3 binding 271..278 3/6 (50%)
9aaTAD. /evidence=ECO:0000269|PubMed:30468856 416..424 2/7 (29%)
EcRNP_001163061.1 NR_DBD_EcR 261..351 CDD:143535 42/93 (45%)
NR_LBD_EcR 420..652 CDD:132736 73/250 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165157554
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24082
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.940

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