Protein Alignment VCP and CDC48

DIOPT Version :10

• Sequence 1: NP_009057.1
• Gene: VCP / 7415
• HGNCID: 12666
• Length: 806
• Species: Homo sapiens
• Sequence 2: NP_010157.1
• Gene: CDC48 / 851431
• SGDID: S000002284
• Length: 835
• Species: Saccharomyces cerevisiae
• Alignment Length: 828
• Identity: 566/828 - (68%)
• Similarity: 693/828 - (83%)
• Gaps: 28/828 - (3%)

Human     2 ASGADSKGDD-LSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRR 65
            |||.|.:.:| .:||||::|.:.|.|:||:|||:||||::::...||:|:||||||||:|||||:
Yeast    11 ASGVDPREEDKTATAILRRKKKDNMLLVDDAINDDNSVIAINSNTMDKLELFRGDTVLVKGKKRK 75

Human    66 EAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNL 130
            :.|.|||.||...|...|:|||||||||:||||:::|.||||:||..||.||||.||:|||||||
Yeast    76 DTVLIVLIDDELEDGACRINRVVRNNLRIRLGDLVTIHPCPDIKYATRISVLPIADTIEGITGNL 140

Human   131 FEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEE 195
            |:|:|||||:|||||:||||.|:||||||.||||||:.:|..|.:||.||:||.|||||.|||||
Yeast   141 FDVFLKPYFVEAYRPVRKGDHFVVRGGMRQVEFKVVDVEPEEYAVVAQDTIIHWEGEPINREDEE 205

Human   196 ESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVAN 260
            .::||||||||||||||:|||:||||||||||.||||||:|||||:|:||||||||||:||||||
Yeast   206 NNMNEVGYDDIGGCRKQMAQIREMVELPLRHPQLFKAIGIKPPRGVLMYGPPGTGKTLMARAVAN 270

Human   261 ETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIV 325
            |||||||||||||:|||:|||||||||||||||||||||||||||:|:|||||:||:||||||:|
Yeast   271 ETGAFFFLINGPEVMSKMAGESESNLRKAFEEAEKNAPAIIFIDEIDSIAPKRDKTNGEVERRVV 335

Human   326 SQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKL 390
            |||||||||:|.|::|:|:|||||||||||||||||||||||||||||||||||:|:||||||||
Yeast   336 SQLLTLMDGMKARSNVVVIAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEVLRIHTKNMKL 400

Human   391 ADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWA 455
            |||||||.:|.||||:||||:|:||||||:|.||:|||||||:::.|||||::||.||||:||:|
Yeast   401 ADDVDLEALAAETHGYVGADIASLCSEAAMQQIREKMDLIDLDEDEIDAEVLDSLGVTMDNFRFA 465

Human   456 LSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPP 520
            |..||||||||||||...|||:|:|||:::|.||:|.|:|||.|||::.|||::|||||||||||
Yeast   466 LGNSNPSALRETVVESVNVTWDDVGGLDEIKEELKETVEYPVLHPDQYTKFGLSPSKGVLFYGPP 530

Human   521 GCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKA 585
            |.||||||||:|.|..|||||:||||||:||:||||:|:|:||||||.|||.|:|.|||||||||
Yeast   531 GTGKTLLAKAVATEVSANFISVKGPELLSMWYGESESNIRDIFDKARAAAPTVVFLDELDSIAKA 595

Human   586 RGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDE 650
            |||::||.|||:|||:||:|||||||:.|||||:||||||||.||||||||||||||||:|||||
Yeast   596 RGGSLGDAGGASDRVVNQLLTEMDGMNAKKNVFVIGATNRPDQIDPAILRPGRLDQLIYVPLPDE 660

Human   651 KSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQT 715
            .:|::||.|.|||:|:...::|..:||.|.|||||||..|.|||.|.||::|||:..:.|.|::.
Yeast   661 NARLSILNAQLRKTPLEPGLELTAIAKATQGFSGADLLYIVQRAAKYAIKDSIEAHRQHEAEKEV 725

Human   716 NPSAMEVE------------EDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRG- 767
            .....:||            |.||||.|.::||.|||:.|:|||||.::|:||.::|.::.|||
Yeast   726 KVEGEDVEMTDEGAKAEQEPEVDPVPYITKEHFAEAMKTAKRSVSDAELRRYEAYSQQMKASRGQ 790

Human   768 FGSFRF---PSG-------NQGGAGPSQGSGGGTGGSVYTEDNDDDLY 805
            |.:|.|   |.|       |...:.|| |:|...|.:.   :.|||||
Yeast   791 FSNFNFNDAPLGTTATDNANSNNSAPS-GAGAAFGSNA---EEDDDLY 834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VCP	NP_009057.1	CDC48	25..764	CDD:273521	536/750 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	708..727		5/30 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	768..806		16/48 (33%)
		Interaction with UBXN6. /evidence=ECO:0000269|PubMed:18656546	797..806		5/9 (56%)
		PIM motif. /evidence=ECO:0000269|PubMed:24726327	802..806		4/4 (100%)
CDC48	NP_010157.1	CDC48	48..785	CDD:273521	527/736 (72%)