DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VCP and comt

DIOPT Version :9

Sequence 1:	NP_009057.1	Gene:	VCP / 7415	HGNCID:	12666	Length:	806	Species:	Homo sapiens
Sequence 2:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster

Alignment Length:	619	Identity:	176/619 - (28%)
Similarity:	283/619 - (45%)	Gaps:	122/619 - (19%)

- Green bases have known domain annotations that are detailed below.

Human   142 AYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLN---EVGY 203
            |.|.:|.|.|.    |...|:|:..|           ::.::.:|:...:...:..:|   :.|.
  Fly   168 AMRNVRFGRIL----GNTVVQFEKAE-----------NSSLNLQGKSKGKVVRQSIINPDWDFGK 217

Human   204 DDIGGCRKQLAQI-KEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAV-----ANET 262
            ..|||..|:...| :......:..|.|.:.:|.|..:||||||||||||||:||.:     |.|.
  Fly   218 MGIGGLDKEFNSIFRRAFASRVFPPELVEQLGCKHVKGILLYGPPGTGKTLMARQIGTMLNAREP 282

Human   263 GAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPA--------IIFIDELDAIAPKREKTHGE 319
            .    ::|||:|:.|..||||:|:|:.|.|||:....        ||..||:|||..:|....|.
  Fly   283 K----IVNGPQILDKYVGESEANVRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKQRGSVAGN 343

Human   320 --VERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQ 382
              |...:|:||||.:||:.|..:::|:..|||.:.||.||.|.||.:.:::|.:|:..||::||.
  Fly   344 SGVHDTVVNQLLTKIDGVDQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILN 408

Human   383 IHTKNM----KLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDE-TIDAEVM 442
            ||||.|    |:.||||.:::|..|....||:|..|...|...|:.:   ||..:.: |:|.|.|
  Fly   409 IHTKRMREFNKINDDVDNKEIAALTKNFSGAELEGLVRAAQSSAMNR---LIKADAKVTVDPEAM 470

Human   443 NSLAVTMDDFRWALSQSNPSA------LRETVVEVPQVTWEDIGG-----LEDVKRELQELVQYP 496
            ..|.|..|||..:|......|      :.:.::....:.|   |.     |||....:|:
  Fly   471 EKLKVNRDDFLHSLEHDIKPAFGTAQEILDNMLARGVINW---GAPVSNLLEDGMLYVQQ----- 527

Human   497 VEHPDKFLKFGMTPSKG---VLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEA- 557
            .:.|:         |.|   ||..|.|..|||.||..:|......|:.:..||.:.   |.:|:
  Fly   528 AKAPE---------SSGLVSVLVAGAPNSGKTALAAQLAKMSDFPFVKVCSPEDMV---GYTESA 580

Human   558 ---NVREIFDKA-RQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTK---- 614
               ::|:|||.| |....|::    :|::.:     :.|.|....|..|..|..:..:..|
  Fly   581 KCLHIRKIFDDAYRSMLSCIV----VDNVER-----LLDYGSIGPRYSNMTLQALLVLLKKQPPK 636

Human   615 -KNVFIIGATNRPDIIDPAILRPGRLDQLIYIP---LPDEKSRVAILKANLRKSPVAKDVDLEFL 675
             :.:.|:..::|.::::...:... ...::::|   .||.      :.|.|..:.:....:::.:
  Fly   637 GRKLLILCTSSRREVLEEMEMLTA-FTSVLHVPNLSKPDH------VLAVLENTDIFSKGEIQAI 694

Human   676 AKMTNG---FSG----------ADLTEICQRACK 696
            .|...|   |.|          |..||..|||.|
  Fly   695 GKKMAGKRVFIGIKKLLGLIDMARQTEQSQRAIK 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VCP	NP_009057.1	CDC48	25..764	CDD:273521	176/619 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..727
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..806
		Interaction with UBXN6. /evidence=ECO:0000269\|PubMed:18656546	797..806
		PIM motif. /evidence=ECO:0000269\|PubMed:24726327	802..806
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011
		SpoVK	242..699	CDD:223540	149/499 (30%)
		AAA	256..397	CDD:278434	62/144 (43%)
		AAA	539..668	CDD:278434	31/141 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810