DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VCP and Pex1

DIOPT Version :9

Sequence 1:	NP_009057.1	Gene:	VCP / 7415	HGNCID:	12666	Length:	806	Species:	Homo sapiens
Sequence 2:	NP_652016.1	Gene:	Pex1 / 45460	FlyBaseID:	FBgn0013563	Length:	1006	Species:	Drosophila melanogaster

Alignment Length:	759	Identity:	213/759 - (28%)
Similarity:	339/759 - (44%)	Gaps:	120/759 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    72 LSDDTCSD--EKIRMNRVVRNNLRVRLG----DVISIQP-CPDVKYGKRIHVLPIDDTVEGITGN 129
            :.||...|  |.|..:..:..||...||    :.:.::| ...|.:.::|.:.....|...|..|
  Fly   298 VEDDIEDDLPETIHPSIELNANLMKLLGIKELERVVLRPKTTVVNFVEKIELFANKKTHYKIMEN 362

Human   130 LFEVYL------KPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIV-----------A 177
            .|:.::      ||........:|..|..||..|:....|:        ||:|           |
  Fly   363 AFKRFVIERTQHKPMLFNQEEVVRLEDDLLVTVGILPEHFR--------YCVVDAQFLKESKIYA 419

Human   178 PDTVIHCEGEPIKREDEEESLNEV-------GYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGV 235
            .| ::...||.||.|....|...|       .||.|      :.|:.:.:.:.|   .|.....|
  Fly   420 AD-LVRPVGEIIKEETPPTSPLSVQDLIQLPEYDKI------VDQVVQELRMNL---CLSADNSV 474

Human   236 KPPRGILLYGPPGTGKTLIARAVANETG-----AFFFLINGPEIMSKLAGESESNLRKAFEEAEK 295
            .....:||.|..|||||::...:.::..     ..|...:|.....:.....:.:||..|....:
  Fly   475 MRQCNVLLAGASGTGKTVLVERILDQLSRKPDYCHFEFFHGSRSKGRKTESIQKDLRNIFTSCLQ 539

Human   296 NAPAIIFIDELDAI---APKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPAL 357
            :||||:.::.||.:   |.::....||...|:...:..|:........:.|:|..|...:::..|
  Fly   540 HAPAIVVLENLDVLAHAAGEQSSQDGEYYNRMADTVYQLIVQYTTNNAIAVIATVNELQTLNKRL 604

Human   358 R---------------RFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHV 407
            .               ...|.|||:            ||:....::.:|.|:||.:.:|.|.|:.
  Fly   605 SSPRGRHVFQTVARLPNLERADREI------------ILRELCSHINVAKDLDLVKFSNLTEGYR 657

Human   408 GADLAALCSEAALQAIR-KKMDLIDLEDETIDA-EVMNSLAVTMDDFRWALS--QSNPSALRETV 468
            ..||......|...|.| .|...:...|:.|:: |..||         :.|.  |||.....:
  Fly   658 KCDLVQFVERAIFYAYRISKTQPLLTNDQLIESLEHTNS---------YCLQGIQSNQRTGND-- 711

Human   469 VEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIAN 533
            .:..::..|::.|||.|...|:|::.:|..:|..|....:....|||.|||||.|||.|...:|.
  Fly   712 ADANEMRVEELPGLESVVGVLEEVLMWPSRYPTIFNASPLRNQAGVLLYGPPGTGKTYLVSQLAT 776

Human   534 ECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAAD 598
            ......||:||||||..:.|:||.|||.:|::||.|.||||||||.||:|..||   .|..|..|
  Fly   777 SWNLRIISVKGPELLAKYIGQSEENVRNLFNRARSARPCVLFFDEFDSLAPKRG---HDSTGVTD 838

Human   599 RVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRK 663
            ||:||:|||:||:...:.|.:|.||:||:::|||:||.||:|:|:..||||..:||.|.:|....
  Fly   839 RVVNQLLTELDGVEGLQGVTVIAATSRPELLDPALLRSGRIDRLVECPLPDAPARVRIFEALSST 903

Human   664 SPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAMEVEEDDPV 728
            ..:.:.||.::.|..|..::|||:..|...|...|::|:: ::...|:      .|.::
  Fly   904 LSLDECVDFDWFAGKTANYTGADIQSILTSANMAAVKEAL-AQFGHEK------LAKKI------ 955

Human   729 PEIRRDHFEEAMRFARRSVSDNDIRKYE----MFAQTLQQSRGF 768
             .:::.|..|:.:..|.|:|.:|:.||.    .|....:.||.|
  Fly   956 -SLKQKHLIESFQTTRPSLSASDVAKYHRTYARFTNKEKTSREF 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VCP	NP_009057.1	CDC48	25..764	CDD:273521	210/753 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..727		2/18 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..806		1/1 (100%)
		Interaction with UBXN6. /evidence=ECO:0000269\|PubMed:18656546	797..806
		PIM motif. /evidence=ECO:0000269\|PubMed:24726327	802..806
Pex1	NP_652016.1	PEX-1N	93..168	CDD:286361
		SpoVK	479..974	CDD:223540	162/534 (30%)
		P-loop_NTPase	480..604	CDD:304359	27/123 (22%)
		AAA	757..887	CDD:278434	70/132 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810