DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VCP and nmd

DIOPT Version :9

Sequence 1:	NP_009057.1	Gene:	VCP / 7415	HGNCID:	12666	Length:	806	Species:	Homo sapiens
Sequence 2:	NP_001285801.1	Gene:	nmd / 44021	FlyBaseID:	FBgn0005322	Length:	369	Species:	Drosophila melanogaster

Alignment Length:	322	Identity:	114/322 - (35%)
Similarity:	167/322 - (51%)	Gaps:	57/322 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   447 VTMDDFRWALSQSNPSA--------LRETVVE---------------------------VP---Q 473
            :|....:|.::|.:|::        |.|..::                           ||   .
  Fly    29 ITYYSVKWMMNQMDPTSKNKKKAKVLAEEQLKRLAEQEGFKLRGQEFSDYELMIASHLVVPADIT 93

Human   474 VTWEDIGGLEDVKRELQELVQYPVEHPD--KFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQ 536
            |:|.||.||:.|.:||:|.|..|::|.|  |..|....| ||||.:|||||||||:|||.|.|..
  Fly    94 VSWADIAGLDSVIQELRESVVLPIQHKDLFKHSKLWQAP-KGVLLHGPPGCGKTLIAKATAKEAG 157

Human   537 ANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVI 601
            ..||::....|...|:|||:.....:|..|.:..||::|.||:||..::|  |:.|....| .:.
  Fly   158 MRFINLDVAILTDKWYGESQKLTSAVFSLASRIEPCIIFIDEIDSFLRSR--NMNDHEATA-MMK 219

Human   602 NQILTEMDGMSTKKN--VFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKS 664
            .|.:...||:||..|  |.::||||||..:|.||:|  |:....:|.||.|..|..|||..|:..
  Fly   220 TQFMMLWDGLSTNANSTVIVMGATNRPQDLDKAIVR--RMPAQFHIGLPSETQRKDILKLILQSE 282

Human   665 PVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAMEVEEDD 726
            .|::||||..|:|:||||||:||.|:|:.|....:|:.|.|.         :|||..::.::
  Fly   283 EVSQDVDLNRLSKLTNGFSGSDLREMCRNASVYRMRQLITSR---------DPSATALDRNN 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VCP	NP_009057.1	CDC48	25..764	CDD:273521	114/322 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..727		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..806
		Interaction with UBXN6. /evidence=ECO:0000269\|PubMed:18656546	797..806
		PIM motif. /evidence=ECO:0000269\|PubMed:24726327	802..806
nmd	NP_001285801.1	AAA	132..266	CDD:214640	58/139 (42%)
nmd	NP_001285801.1	AAA	135..265	CDD:278434	55/134 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810