DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VCP and spas

DIOPT Version :9

Sequence 1:	NP_009057.1	Gene:	VCP / 7415	HGNCID:	12666	Length:	806	Species:	Homo sapiens
Sequence 2:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster

Alignment Length:	648	Identity:	167/648 - (25%)
Similarity:	280/648 - (43%)	Gaps:	145/648 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   192 EDEEESLN---EVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAI------GVKPPRGILLYGPP 247
            :::::|||   |:..:. .|..:||:          ..|..|:.|      ..:|..|.    .|
  Fly   170 KEQQQSLNHPSELNREG-DGQEQQLS----------NQPQRFRPIQPLEMAANRPGGGY----SP 219

Human   248 GTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNL---RKAFEEAEKNAPAIIFIDELDAI 309
            |.|..|:|:...:...||.::....:|..:..|..|..:   ||..:|.|            |.|
  Fly   220 GPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELE------------DGI 272

Human   310 A-----------PKREKTHGEV-----------------ERRIVSQLLTLMDGLKQRA------- 339
            |           .:.::.|.::                 |:.:..|.|:|.:..|:.|
  Fly   273 AVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEEAQSKPQKT 337

Human   340 -HVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKN-MKLADDVDLEQVANE 402
             ..::...||.|..:  .:|..|...:......|.|:||.  |.|.:|. :.||       |||:
  Fly   338 REPMLAGMTNEPMKL--RVRSSGYGPKATTSAQPTASGRK--LTIGSKRPVNLA-------VANK 391

Human   403 TH---GHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSA- 463
            :.   .::|       |:.::.|::::..........:..:..:.........|..::.:.||.
  Fly   392 SQTLPRNLG-------SKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGS 449

Human   464 --------------------LRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGM 508
                                |.|.|....:|.|.||.|.:..|:.|||:|..|...|:.|.  |:
  Fly   450 GASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFT--GL 512

Human   509 -TPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPC 572
             .|:||:|.:||||.||||||:|:|.||.|.|::|....|.:.:.|:.|..||.:|..||...|.
  Fly   513 RAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPS 577

Human   573 VLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKN---VFIIGATNRPDIIDPAIL 634
            ::|.||:||:...|..:..:   |:.|:..:.|.|.||:....:   :.::.|||||..:|.|.|
  Fly   578 IIFIDEVDSLLSERSSSEHE---ASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAAL 639

Human   635 RPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVD-LEFLAKMTNGFSGADLTEICQRACKLA 698
            |  |..:.:|:.||||::|..:|...|:|.....|.: |..|||:|:|:||:|||.:.:.|....
  Fly   640 R--RFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEP 702

Human   699 IRESIESEIRRERERQTNPSAME-VEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQ 760
            ||     |:..|:.:..:.|||. :.|.|         |..:::..||||:...:..||.::|
  Fly   703 IR-----ELNVEQVKCLDISAMRAITEQD---------FHSSLKRIRRSVAPQSLNSYEKWSQ 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VCP	NP_009057.1	CDC48	25..764	CDD:273521	167/648 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..727		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..806
		Interaction with UBXN6. /evidence=ECO:0000269\|PubMed:18656546	797..806
		PIM motif. /evidence=ECO:0000269\|PubMed:24726327	802..806
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	13/89 (15%)
		P-loop_NTPase	482..>538	CDD:304359	28/57 (49%)
		AAA	515..652	CDD:214640	54/141 (38%)
		AAA	519..650	CDD:278434	50/135 (37%)
		Vps4_C	<722..754	CDD:286426	10/39 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810