DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VCP and Nsf2

DIOPT Version :9

Sequence 1:	NP_009057.1	Gene:	VCP / 7415	HGNCID:	12666	Length:	806	Species:	Homo sapiens
Sequence 2:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster

Alignment Length:	616	Identity:	176/616 - (28%)
Similarity:	278/616 - (45%)	Gaps:	133/616 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   144 RPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLN---EVGYDD 205
            |.:|.|.|.    |...|:|:..|           ::|::.:|....:...:..:|   :.|...
  Fly   175 RNVRFGRIL----GNTVVQFEKAE-----------NSVLNLQGRSKGKIVRQSIINPDWDFGKMG 224

Human   206 IGGCRKQL-AQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAV-----ANETGA 264
            |||..|:. |..:......:..|.|.:.:|:|..:||||||||||||||:||.:     |.|..
  Fly   225 IGGLDKEFNAIFRRAFASRVFPPELVEQLGIKHVKGILLYGPPGTGKTLMARQIGTMLNAREPK- 288

Human   265 FFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPA--------IIFIDELDAIAPKREKTHGE-- 319
               ::|||:|:.|..||||:|:|:.|.|||:....        ||..||:|||...|....|.
  Fly   289 ---IVNGPQILDKYVGESEANIRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKARGSVAGNSG 350

Human   320 VERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIH 384
            |...:|:|||..:||::|..:::|:..|||.:.||.||.|.||.:.:::|.:|:..||::||.||
  Fly   351 VHDTVVNQLLAKIDGVEQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIH 415

Human   385 TKNM----KLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDET-IDAEVMNS 444
            ||.|    |:|.|||..::|.:|....||:|..|...|...|:.:   ||..:.:. :|.|.|..
  Fly   416 TKRMRDFNKIASDVDNNEIAAKTKNFSGAELEGLVRAAQSTAMNR---LIKADSKVHVDPEAMEK 477

Human   445 LAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKREL--QELVQY--PVEHPDKFLK 505
            |.||..||..||......|               .|..:::...|  :.::.:  ||   .:.|:
  Fly   478 LRVTRADFLHALDNDIKPA---------------FGAAQEMLENLLARGIINWGPPV---TELLE 524

Human   506 FGM--------TPSKG---VLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESE--A 557
            .||        |.|.|   ||..|.|..||:.||..:|......|:.:..||.: :.|.||.  .
  Fly   525 DGMLSVQQAKATESSGLVSVLIEGAPNSGKSALAANLAQLSDFPFVKVCSPEDM-VGFTESAKCL 588

Human   558 NVREIFDKA-RQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVIN------------------- 602
            ::|:|||.| |....|::    :|::.:     :.|.|....|..|
  Fly   589 HIRKIFDDAYRSTLSCIV----VDNVER-----LLDYGPIGPRYSNLTLQALLVLLKKQPPKGRK 644

Human   603 ----------QILTEMDGMSTKKNVFIIGATNRPDII-----DPAILRPGRLDQLIYIPLPDEKS 652
                      .:|.||:.:|...:|..:...:.|:.:     |..:..|..| |.|...:..::.
  Fly   645 LLILCTSSRRDVLEEMEMLSAFTSVLHVSNLSTPENVLAVLDDSDLFSPEEL-QSIARKMAGKRL 708

Human   653 RVAILKA-----NLRKSPVAKDVDLEFLAKM 678
            .:.|.|.     .:|:|...:.| ::||:||
  Fly   709 CIGIKKLLALIDMIRQSEPHQRV-IKFLSKM 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VCP	NP_009057.1	CDC48	25..764	CDD:273521	176/616 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..727
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..806
		Interaction with UBXN6. /evidence=ECO:0000269\|PubMed:18656546	797..806
		PIM motif. /evidence=ECO:0000269\|PubMed:24726327	802..806
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012
		CDC48_2	117..>170	CDD:215011
		AAA	259..404	CDD:214640	62/148 (42%)
		AAA	261..402	CDD:278434	61/144 (42%)
		AAA	543..674	CDD:214640	32/140 (23%)
		P-loop_NTPase	544..>613	CDD:304359	23/78 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810