DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VCP and CG16789

DIOPT Version :9

Sequence 1:	NP_009057.1	Gene:	VCP / 7415	HGNCID:	12666	Length:	806	Species:	Homo sapiens
Sequence 2:	NP_649910.3	Gene:	CG16789 / 41154	FlyBaseID:	FBgn0037712	Length:	831	Species:	Drosophila melanogaster

Alignment Length:	466	Identity:	102/466 - (21%)
Similarity:	169/466 - (36%)	Gaps:	107/466 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    18 KQKNRPNRLIVDEAINEDNSVVSLSQPKM------DELQLFRGDTVLLK---GKKRREAVCIVLS 73
            |...|...|.|:|  |:|..|.....|.:      .|:.|| .||...|   |...:.|...::.
  Fly   377 KSPARSGDLNVNE--NQDEEVSFQPAPSVCLPDIRAEIDLF-NDTWRDKDETGVLSQAAYEDMIY 438

Human    74 DDTCSDEKIRMNRVVRNNLR-------VRLGDVISIQPCPDVKYGKRIHVLPIDD-TVEGITGNL 130
            .|...:.::...|.|.:.:|       ..:|..:........:.||:.......| |.:..|.:|
  Fly   439 SDKYQEVELEFRRAVDDVMRQEIELLQTAVGKKVKKSSKKTRRSGKKSKKKKEKDLTPDRTTESL 503

Human   131 FEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSP---------YCIVAPDTVIHCEG 186
            :|..:....:..|..:|... ||   |.:|:..: :.|:|||         |||:
  Fly   504 YEELVTNGIIRKYPELRLKQ-FL---GDKALTAR-IGTNPSPGDIRQILTEYCIL---------- 553

Human   187 EPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGK 251
                         .:|.|.|..|...:                         |.|||.||.|:||
  Fly   554 -------------PLGSDAIHNCTPLI-------------------------RSILLAGPKGSGK 580

Human   252 TLIARAVANETGAFFFLINGPEIMSKLAGESE--SNLRKAFEEAEKNAPAIIFIDELDAIAP--- 311
            ..:..|:..|.||..|.:....|:.|..|:|.  ..:....:.:....||:||:.  ||..|
  Fly   581 KALLHAICTEVGAVLFDLTPANIVGKYPGKSGLIMLIHLVLKVSRLLQPAVIFMG--DAERPFMK 643

Human   312 KREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATG 376
            |..||.....:|:...|..|:..:.....|:.:..:|.|...|..|.: ..::|.:.|..|| .|
  Fly   644 KIPKTDRTDPKRLKKDLPKLIKNIAPEDRVVFIGTSNLPWEADQKLLQ-SVYNRFIYIPRPD-YG 706

Human   377 RLEILQIHTKNMKLAD------DVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDE 435
            .:.    |.....|.|      ::|...:|..:.|:....:.| |.:..:...||    :.|..:
  Fly   707 AMS----HAWKTLLHDYSGGISNLDTSAMAKISDGYTIGSIDA-CLKEVMTCKRK----LQLRTQ 762

Human   436 TI-DAEVMNSL 445
            .: :||::|.|
  Fly   763 PLTNAELINVL 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VCP	NP_009057.1	CDC48	25..764	CDD:273521	100/459 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..727
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..806
		Interaction with UBXN6. /evidence=ECO:0000269\|PubMed:18656546	797..806
		PIM motif. /evidence=ECO:0000269\|PubMed:24726327	802..806
CG16789	NP_649910.3	AAA	568..704	CDD:214640	38/138 (28%)
CG16789	NP_649910.3	AAA	570..702	CDD:278434	37/134 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900