DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VCP and pch2

DIOPT Version :9

Sequence 1:	NP_009057.1	Gene:	VCP / 7415	HGNCID:	12666	Length:	806	Species:	Homo sapiens
Sequence 2:	NP_001287235.1	Gene:	pch2 / 41013	FlyBaseID:	FBgn0051453	Length:	421	Species:	Drosophila melanogaster

Alignment Length:	245	Identity:	67/245 - (27%)
Similarity:	108/245 - (44%)	Gaps:	46/245 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   489 LQELVQYPVEHPDKFLKFGMTP---------------SKGVLFYGPPGCGKTLLAKAIANE---- 534
            |.|.:.|.....:|.|||.::.               ::.:|.:||||.|||.|.||:|.:
  Fly   129 LWENLIYETGLKEKLLKFALSALMFSEHRVDTNVIACNRLILLHGPPGTGKTSLCKALAQKLSIR 193

Human   535 -----CQANFISIKGPELLTMWFGESEANVREIFDKARQAAP------CVLFFDELDSIAKARGG 588
                 ...:.:.|....|.:.||.||...|.::|:|..:...      ||| .||::|:|.||..
  Fly   194 TQGSYAYTHLVEINSHSLFSKWFSESGKLVAQLFNKIAELVSDPNNLVCVL-IDEVESLAYARSA 257

Human   589 NIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPD---- 649
            ...:....|.||:|.:||::|.:.|..||.|:..:|....||.|.:  .|.|..::|..|.
  Fly   258 MSSNEPRDAMRVVNAVLTQLDSLKTCPNVLILATSNLAQSIDLAFV--DRADIRLFIGYPGISAI 320

Human   650 ---------EKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEI 690
                     |.....:|:..:.:|..|::..|..||:.:.|.||..|.::
  Fly   321 REIYKGMLAELMSAGVLQREVLESEDAEEGLLTQLAERSVGLSGRTLRKL 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VCP	NP_009057.1	CDC48	25..764	CDD:273521	67/245 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..727
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..806
		Interaction with UBXN6. /evidence=ECO:0000269\|PubMed:18656546	797..806
		PIM motif. /evidence=ECO:0000269\|PubMed:24726327	802..806
pch2	NP_001287235.1	AAA	166..315	CDD:214640	48/151 (32%)
pch2	NP_001287235.1	AAA	169..314	CDD:278434	48/147 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810