DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VCP and CG14183

DIOPT Version :9

Sequence 1:	NP_009057.1	Gene:	VCP / 7415	HGNCID:	12666	Length:	806	Species:	Homo sapiens
Sequence 2:	NP_649172.3	Gene:	CG14183 / 40192	FlyBaseID:	FBgn0036931	Length:	872	Species:	Drosophila melanogaster

Alignment Length:	279	Identity:	65/279 - (23%)
Similarity:	126/279 - (45%)	Gaps:	42/279 - (15%)

- Green bases have known domain annotations that are detailed below.

Human   195 EESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVA 259
            :::.:|.|...:|..:   ..||.:::..:.....|   .|..|:.:||.||..:||.|:...:|
  Fly   582 DDTRDEDGLTTLGPAK---GDIKMVIQESMLGMGEF---DVPKPKSLLLIGPLNSGKRLLCEIIA 640

Human   260 NETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHG-EVERR 323
            :|..|.|..:: ||...|.|.:.:..|....:.|:...|.|::|:|...:..|:..... |:..|
  Fly   641 SELDAVFMNLS-PENTYKYAKDLKYFLHVILKVAKAFQPTIMYIEEAHRLFWKKVPPEAVEINPR 704

Human   324 IVSQLLT--LMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDR-----EVDIGIPDATGRLEIL 381
            ::...|.  ::..||:...::::..:|.|.:.:..::|  .|.:     :.|.|    |..|..|
  Fly   705 LLGTSLASKILKPLKKNDKIVLVGTSNMPWAANGGIKR--AFQKVLLIPKCDYG----TSFLLWL 763

Human   382 QIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDET--IDAEV-MN 443
            ::.|:|   |.| |:::.|......|            |||.... |:.|...||  ||.:: :.
  Fly   764 ELMTEN---APD-DMKEYAYSALARV------------LQAYNSG-DIDDNVKETLNIDRKMRLK 811

Human   444 SLAVTMDDF-RWALSQSNP 461
            :.|:..::| .:.||::.|
  Fly   812 NEALDPNEFLEYFLSKNEP 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VCP	NP_009057.1	CDC48	25..764	CDD:273521	65/279 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..727
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..806
		Interaction with UBXN6. /evidence=ECO:0000269\|PubMed:18656546	797..806
		PIM motif. /evidence=ECO:0000269\|PubMed:24726327	802..806
CG14183	NP_649172.3	AAA	622..751	CDD:278434	31/131 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900