DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VCP and smid

DIOPT Version :9

Sequence 1:	NP_009057.1	Gene:	VCP / 7415	HGNCID:	12666	Length:	806	Species:	Homo sapiens
Sequence 2:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster

Alignment Length:	709	Identity:	252/709 - (35%)
Similarity:	365/709 - (51%)	Gaps:	161/709 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   190 KREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLI 254
            ||:.|.:...| .:.||||....|.::.||: :.::.|..:..:|:.|.||:||:||||.|||.:
  Fly   238 KRDLEVQHPTE-SFRDIGGMDSTLKELCEML-IHIKSPEFYFQLGLLPSRGLLLHGPPGCGKTFL 300

Human   255 ARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGE 319
            |||::.:.......|...|::..::||||..:|:.|::|...:|.::||||:|||...|:....:
  Fly   301 ARAISGQLKMPLMEIPATELIGGISGESEERIREVFDQAIGYSPCVLFIDEIDAIGGNRQWASKD 365

Human   320 VERRIVSQLLTLMDGLKQR---AHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEIL 381
            :||||||||::.:|.||..   ..|:|:|||.||:.:||.|||.||||.|:.|.||....|.|||
  Fly   366 MERRIVSQLISSLDNLKANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREIL 430

Human   382 QIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIR---------------KKMDLID 431
            :|..:.:.:...::.:::|..|.|:|||||.||.|.||..|::               |.|..:.
  Fly   431 RIQCEGLSVDPKLNYDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVT 495

Human   432 LED-------------------------------------------------------------- 434
            |:|
  Fly   496 LDDDEPSEDAGETPVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSI 560

Human   435 ----------------------------------ETID-------------AEVMNSL------- 445
                                              :.:|             ||:.|.|
  Fly   561 KSPQKTPKKSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEF 625

Human   446 -----AVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLK 505
                 .:|:.||..|:....|||.||..:.||..||:|||.||.::.||:..|..||::|:...:
  Fly   626 ADPNFCLTLIDFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLER 690

Human   506 FGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAA 570
            .|:|...|||..|||||||||||||||||...||||:|||||:.|:.||||..||..|.:||.:|
  Fly   691 LGLTAPSGVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSA 755

Human   571 PCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILR 635
            |||:||||.||:...|... |||..:..|::||:||||||:..:|.|:|:.||||||||||||||
  Fly   756 PCVIFFDEFDSLCPKRSDG-GDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILR 819

Human   636 PGRLDQLIYIPLPDEKSRVAILKANLR--KSPV-AKDVDLEFLAKMTNGFSGADLTEICQRACKL 697
            |||||.::|:..|::..|..||||..:  |.|| |.||||:.:|..|.|::||||..:.::|...
  Fly   820 PGRLDTILYVGFPEQSERTEILKATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQASMF 884

Human   698 AIRESIESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYE 756
            ::|:|:.:.              :...||..  :|..||:||::..|.||::.|.:.|:
  Fly   885 SLRQSLNNG--------------DTNLDDLC--VRSQHFQEALQQLRPSVNEQDRKIYD 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VCP	NP_009057.1	CDC48	25..764	CDD:273521	252/709 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..727		1/18 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..806
		Interaction with UBXN6. /evidence=ECO:0000269\|PubMed:18656546	797..806
		PIM motif. /evidence=ECO:0000269\|PubMed:24726327	802..806
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	238/664 (36%)
		AAA	287..418	CDD:278434	58/130 (45%)
		P-loop_NTPase	679..>716	CDD:304359	20/36 (56%)
		AAA	699..830	CDD:278434	84/131 (64%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820