DRSC/TRiP Functional Genomics Resources

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Protein Alignment VCP and CG12010

DIOPT Version :9

Sequence 1:NP_009057.1 Gene:VCP / 7415 HGNCID:12666 Length:806 Species:Homo sapiens
Sequence 2:NP_728878.1 Gene:CG12010 / 38421 FlyBaseID:FBgn0035443 Length:717 Species:Drosophila melanogaster


Alignment Length:570 Identity:182/570 - (31%)
Similarity:289/570 - (50%) Gaps:79/570 - (13%)


- Green bases have known domain annotations that are detailed below.


Human   211 KQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIM 275
            :||.::.|..::...|         :.|...|:.||...||:.:............|.|...:::
  Fly   202 EQLEKLLETSKISFSH---------RFPTTALVVGPVDCGKSGLLSEFLRRHSCNCFYITASQVL 257

Human   276 SKLAGESESNLRKAFEEAE-------KNAPAIIFIDELDAIAPK---REKTHGEVERRIVSQLLT 330
            ....||:|..||:.|:.|:       ...|.:|.|::|:.:.|.   .:..:.....||.::|..
  Fly   258 RSYPGETEEELRRIFQAAQTFKEKLRPLLPIVILIEDLELLCPSTAVADAKNSSNSLRISAELYK 322

Human   331 LMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEIL----QIHTKNMKLA 391
            |:|.|.:  .:|.:|.:..|:|:....||  ||.|||.|.:|....|.:::    ::|..|:   
  Fly   323 LLDALPR--GIICLATSGVPDSLHEHARR--RFVREVTINMPSEGQRRQLVEHLCEVHELNI--- 380

Human   392 DDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWAL 456
            ....||.:|..|.|:|.|||..|......|.:.|  |..|:|                ..|..:|
  Fly   381 SQTLLEHIARNTQGYVIADLTLLLRRVQQQLLTK--DDFDIE----------------HIFLKSL 427

Human   457 SQSNPSALRETVVEVPQVT--WEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGP 519
            ||:.|||.|.|.|.|.::|  :|.|||:|.:||.||..|...:.....|.:||::..||||.|||
  Fly   428 SQTQPSASRSTDVRVSKMTAGFEVIGGMEALKRTLQVSVLAGIRQSAAFARFGLSLPKGVLLYGP 492

Human   520 PGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAK 584
            |||.||.:||.:|.|....||:....|:.:.:.|.:|..:..|||.||:.|||::|.||:||:..
  Fly   493 PGCAKTTVAKCLAKEADMTFIATSAAEVYSPYVGCAERFISRIFDTARKNAPCLIFLDEIDSLVG 557

Human   585 ARGGNIGDGGGAAD-RVINQILTEMDGM---STKKNVFIIGATNRPDIIDPAILRPGRLDQLIYI 645
            .|..:.|.|||... |:::.:||||:|:   .:::::.::.||||||:||.|:|||||.|:||::
  Fly   558 RRTVSSGGGGGQVQLRILSTLLTEMNGIVGGGSQQHILVVAATNRPDMIDDALLRPGRFDKLIHV 622

Human   646 PLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRE 710
            |.||||||:|:||.:.::.|..::|.|:.:|..|:.:|||||..:|                   
  Fly   623 PAPDEKSRLALLKLHSQRMPFHENVFLQEIAARTDRYSGADLCNLC------------------- 668

Human   711 RERQTNPSAMEV-EEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFA 759
                 |.:|:|. :.|....||....||:.:...:.|::.:.|..|..||
  Fly   669 -----NEAAIEAFQRDFKATEIELQDFEKVLTKQKSSLTQSQIDGYYKFA 713

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VCPNP_009057.1 CDC48 25..764 CDD:273521 182/570 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 708..727 4/19 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 768..806
Interaction with UBXN6. /evidence=ECO:0000269|PubMed:18656546 797..806
PIM motif. /evidence=ECO:0000269|PubMed:24726327 802..806
CG12010NP_728878.1 SpoVK 201..707 CDD:223540 178/562 (32%)
AAA 224..357 CDD:278434 36/136 (26%)
AAA 487..623 CDD:278434 60/135 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0464
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D169540at33208
OrthoFinder 1 1.000 - - FOG0000137
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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