DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VCP and YME1L

DIOPT Version :9

Sequence 1:	NP_009057.1	Gene:	VCP / 7415	HGNCID:	12666	Length:	806	Species:	Homo sapiens
Sequence 2:	NP_001246473.1	Gene:	YME1L / 37636	FlyBaseID:	FBgn0034792	Length:	740	Species:	Drosophila melanogaster

Alignment Length:	446	Identity:	138/446 - (30%)
Similarity:	205/446 - (45%)	Gaps:	90/446 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    42 SQPKMDELQLFRGDTVLLKGKKRREAVCIVL------------SDDTCSDEKIR----------M 84
            ||.::::::.|:.|..:...:||...:...|            .|.....||:|          .
  Fly   158 SQQQLNQIRGFKTDRSIEAEQKRNPTMTSRLKNALANSPQRLDGDTPLQAEKLRRLLAKSEEHGF 222

Human    85 NRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKG 149
            |:.....:....|.:.:.......|.||.:..|....|:..|.     |:|..:.  ::.....|
  Fly   223 NKAESLKIAFAEGYLAAANSEDSPKSGKTMKYLKTLQTIVVIV-----VFLGIFL--SFFTTSNG 280

Human   150 DIFLVRGGMRAVEF-KVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQL 213
            .:|      |:::. ..||.||                         |.:| |.::|:.||.:..
  Fly   281 SVF------RSIQLGNQVEVDP-------------------------EEIN-VTFEDVKGCDEAK 313

Human   214 AQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKL 278
            .::||:||. |:.|..|..:|.|.|:|:||.|||||||||:|||||.|....||...|||....|
  Fly   314 QELKEVVEF-LKSPEKFSNLGGKLPKGVLLVGPPGTGKTLLARAVAGEAKVPFFHAAGPEFDEVL 377

Human   279 AGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKT--HGEVERRIVSQLLTLMDGLKQRAHV 341
            .|:....:|..|:.|:..||.:|||||:|::..||..:  | ....:.::|||:.|||..|.|.|
  Fly   378 VGQGARRVRDLFKAAKARAPCVIFIDEIDSVGAKRTNSVLH-PYANQTINQLLSEMDGFHQNAGV 441

Human   342 IVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGH 406
            ||:.||||.:.:|.||.|.||||.||.:..||.|||.|||.::...: |.|::||:.:|..|.|.
  Fly   442 IVLGATNRRDDLDQALLRPGRFDVEVMVSTPDFTGRKEILSLYLTKI-LHDEIDLDMLARGTSGF 505

Human   407 VGADLAALCSEAALQAI-----------------------RKKMDLIDLEDETIDA 439
            .||||..:.::|||:|.                       .:|..|.|.|..||.|
  Fly   506 TGADLENMINQAALRAAIDGAETVSMKHLETARDKVLMGPERKARLPDEEANTITA 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VCP	NP_009057.1	CDC48	25..764	CDD:273521	138/446 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..727
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..806
		Interaction with UBXN6. /evidence=ECO:0000269\|PubMed:18656546	797..806
		PIM motif. /evidence=ECO:0000269\|PubMed:24726327	802..806
YME1L	NP_001246473.1	FtsH_fam	254..736	CDD:273520	122/350 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910