DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VCP and CG4701

DIOPT Version :9

Sequence 1:	NP_009057.1	Gene:	VCP / 7415	HGNCID:	12666	Length:	806	Species:	Homo sapiens
Sequence 2:	NP_609721.1	Gene:	CG4701 / 34858	FlyBaseID:	FBgn0028868	Length:	384	Species:	Drosophila melanogaster

Alignment Length:	287	Identity:	99/287 - (34%)
Similarity:	156/287 - (54%)	Gaps:	11/287 - (3%)

- Green bases have known domain annotations that are detailed below.

Human   474 VTWEDIGGLEDVKRELQELVQYPVEHPDKF--LKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQ 536
            ::|.||.||:...:||:|.|..||.|...|  .|....| ||||.:|||||||||:|||||.:..
  Fly    92 ISWSDIAGLDGTIQELRETVVLPVRHRKLFSRSKLWRAP-KGVLLHGPPGCGKTLIAKAIAKDAG 155

Human   537 ANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVI 601
            ..||::....|...|:|||:.....:|..|::..||::|.||::|..:.||.|..:   |...:.
  Fly   156 MRFINLDVGVLTDKWYGESQKLATAVFTLAKKLQPCIIFIDEIESFLRMRGSNDHE---ATAMIK 217

Human   602 NQILTEMDGMSTKKN--VFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKS 664
            .|.:.:.||:.:..|  |.::||||||..:|.||||  |:....:|.:|.:..|..||:..|:..
  Fly   218 TQFMLQWDGLMSNTNICVLVLGATNRPQDLDKAILR--RMPAQFHIGVPRDCQRREILQLILQTE 280

Human   665 PVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAMEVEEDDPVP 729
            .::..|:|:.||::|.||||:||.|:|:.|....:|:.:..::....|...:....:.|..|...
  Fly   281 QLSPSVNLKELARLTIGFSGSDLRELCRHASMYRMRQFMREKLNTGEEIGKDKIEWDFEVKDQAL 345

Human   730 EIRRDHFEEAMRFARRSVSDNDIRKYE 756
            : ..:|.|..|....:|:|.....|::
  Fly   346 Q-EWEHLEIQMEDLLKSLSVMKASKHQ 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VCP	NP_009057.1	CDC48	25..764	CDD:273521	99/287 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..727		2/18 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..806
		Interaction with UBXN6. /evidence=ECO:0000269\|PubMed:18656546	797..806
		PIM motif. /evidence=ECO:0000269\|PubMed:24726327	802..806
CG4701	NP_609721.1	Parvo_NS1	47..>152	CDD:305166	32/60 (53%)
		AAA	130..265	CDD:214640	56/140 (40%)
		AAA	133..265	CDD:278434	53/136 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810