DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VCP and CG5776

DIOPT Version :9

Sequence 1:	NP_009057.1	Gene:	VCP / 7415	HGNCID:	12666	Length:	806	Species:	Homo sapiens
Sequence 2:	NP_001260420.1	Gene:	CG5776 / 34680	FlyBaseID:	FBgn0032450	Length:	799	Species:	Drosophila melanogaster

Alignment Length:	821	Identity:	254/821 - (30%)
Similarity:	414/821 - (50%)	Gaps:	140/821 - (17%)

- Green bases have known domain annotations that are detailed below.

Human     4 GADSKGD-----DLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKK 63
            |.||:.:     .:.|..|:|:|.....:.|......|.:|.:|:..|...||..|..|:|:...
  Fly    45 GPDSEAEYVRSGAIYTRSLQQRNFEVESLKDLPTKYANMLVFVSEGAMQLAQLHIGQHVVLEAPS 109

Human    64 RREAVCIVLSDDTC-----------SDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRI--- 114
            ..|...:.:...|.           .|.|:...:     ||.:|..:.::.|       .|:
  Fly   110 TAEQPLVRIVWPTSEQFLTTVFVSEGDFKLHCTQ-----LRGKLLKISALHP-------SRLTAA 162

Human   115 ------HVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDI---------------------F 152
                  ||            |..|..||...|:....:.|.|:                     |
  Fly   163 ASISLKHV------------NTTETSLKSVQLQDAIALLKRDMVNRVFYKDSLIHMNFFNKSLTF 215

Human   153 LVRGGMRAVEFKV----VETDPSPYCIVAPDTVIHCEGEPIKREDEEESL-NEVGYDDIGGCRKQ 212
            .:......||..:    :::.|..:..|...|.:|...:...:::||:.: :.:....|||..:|
  Fly   216 RLERWQSTVEEALAGLSLDSKPLQFIQVTNVTKLHLITDDANQQEEEQKISHRITKCQIGGLDRQ 280

Human   213 LAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIAR---AVANETG---AFFFLING 271
            |..::|.:|..|....|  ..|::..||:||||..|.||:::..   |||.|..   .....||.
  Fly   281 LQLVEESMEYALGFRTL--PAGLRVSRGLLLYGATGCGKSMVLEAMCAVAEERSQGHVQLIRINS 343

Human   272 PEIMSKLAGESESNLRKAFEEAEKN--APAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDG 334
            .|:.||..||:|..|...||.|..:  .|.::.|:::..:.||:|  :.::.:|:....|:|:|.
  Fly   344 GEVYSKFLGETEQKLGAIFERAYNHYPHPTLLLIEDVHNLCPKQE--NSDLVKRVSLAFLSLLDQ 406

Human   335 LKQRAHV-----IVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNM--KLAD 392
            |...:.:     .|:|.:::.:::.|::||.||.|.||::|.|.:..||||::...|::  :|:|
  Fly   407 LSSPSQLKGSKTFVLATSSQIDTLHPSIRRAGRLDNEVELGAPSSQARLEIVRCLIKSVEHQLSD 471

Human   393 DVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALS 457
            : ::|.||:.|||:||||||.|...|.|||....:.:..|:.                    ||:
  Fly   472 E-EVEHVASITHGYVGADLANLVYAAMLQAQPNPLQMPHLQA--------------------ALT 515

Human   458 QSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGC 522
            :..|||:||.::|.|.|.|.||||..:::..:|:.:::|:.|.|||.:.|:.|.:|:|.:|||||
  Fly   516 RIKPSAMREVLIECPNVQWSDIGGQSELRLAMQQAIEWPLLHADKFQRLGIKPPRGILMFGPPGC 580

Human   523 GKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIA--KA 585
            .||::|||:|.|.:.||:|||||||.:||.||||..|||:|.||||.||.::||||:|:|.  ::
  Fly   581 SKTMIAKALATESKLNFLSIKGPELFSMWVGESERAVREVFRKARQVAPAIVFFDEIDAIGGERS 645

Human   586 RGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDE 650
            .|.....|....:||:.|:|||:||:...:||.|:.||||||:||.|:|||||:|:::|:.||..
  Fly   646 EGDGSSSGSSVKERVLTQLLTELDGVEALQNVTIVAATNRPDMIDKALLRPGRIDRILYVGLPQC 710

Human   651 KSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQT 715
            ::|..|||..||..|::.|||:|.|.::|.|:|||::..:|..|...|:.:|.|:|
  Fly   711 EARREILKIKLRAMPISNDVDMEKLVQLTEGYSGAEIQAVCHEAALRALEQSFEAE--------- 766

Human   716 NPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYE 756
                          :::...||.|::......|...::.||
  Fly   767 --------------DVKWTDFEHALKAVPPRTSPELLKLYE 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VCP	NP_009057.1	CDC48	25..764	CDD:273521	247/795 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..727		0/18 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..806
		Interaction with UBXN6. /evidence=ECO:0000269\|PubMed:18656546	797..806
		PIM motif. /evidence=ECO:0000269\|PubMed:24726327	802..806
CG5776	NP_001260420.1	SpoVK	288..785	CDD:223540	201/544 (37%)
		AAA	307..447	CDD:278434	43/141 (30%)
		AAA	572..707	CDD:278434	73/134 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S74
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.770