DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VCP and CG4908

DIOPT Version :9

Sequence 1:	NP_009057.1	Gene:	VCP / 7415	HGNCID:	12666	Length:	806	Species:	Homo sapiens
Sequence 2:	NP_609358.1	Gene:	CG4908 / 34360	FlyBaseID:	FBgn0032195	Length:	431	Species:	Drosophila melanogaster

Alignment Length:	172	Identity:	52/172 - (30%)
Similarity:	79/172 - (45%)	Gaps:	17/172 - (9%)

- Green bases have known domain annotations that are detailed below.

Human   205 DIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLI 269
            |.|..::.:|..::.::..|    .:...|:...||.|||||||.||:....|:|.|......|:
  Fly   195 DRGTSQRIIADCQDFIKSSL----WYTQRGIPYRRGYLLYGPPGCGKSSFITALAGELEYSVCLL 255

Human   270 NGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGE------VERRIVSQL 328
            |..|     .|.::..|......|.:.  :||.::::||....||.|..:      :.|...|.|
  Fly   256 NLSE-----RGLTDDRLNHLLNVAPEQ--SIILLEDIDAAFVSREATPQQKSAFDGLNRITFSGL 313

Human   329 LTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIG 370
            |..:||:......||...||..:.:||||.|.||.|.:..||
  Fly   314 LNCLDGVGSTEARIVFMTTNYIDRLDPALVRPGRIDLKEYIG 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VCP	NP_009057.1	CDC48	25..764	CDD:273521	52/172 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..727
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..806
		Interaction with UBXN6. /evidence=ECO:0000269\|PubMed:18656546	797..806
		PIM motif. /evidence=ECO:0000269\|PubMed:24726327	802..806
CG4908	NP_609358.1	BCS1_N	23..192	CDD:214980
CG4908	NP_609358.1	RecA-like_BCS1	202..354	CDD:410918	48/162 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910