DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VCP and Fign

DIOPT Version :9

Sequence 1:	NP_009057.1	Gene:	VCP / 7415	HGNCID:	12666	Length:	806	Species:	Homo sapiens
Sequence 2:	NP_001259995.1	Gene:	Fign / 33544	FlyBaseID:	FBgn0031519	Length:	523	Species:	Drosophila melanogaster

Alignment Length:	398	Identity:	118/398 - (29%)
Similarity:	195/398 - (48%)	Gaps:	57/398 - (14%)

- Green bases have known domain annotations that are detailed below.

Human   394 VDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTM--------- 449
            :|.:|.::|:....|........:..:..::||......|.:.:...:||....|:
  Fly   138 IDAQQYSSESSSQSGFGFRTAREQLIMDELKKKNRQATSEVDAVPTGMMNFRKKTLGGKRTVSSN 202

Human   450 --------DDFRWALSQSNPSALR------------ETVVEVPQVTWEDIGGLEDVKRELQELVQ 494
                    |:...:.|.|.|.||.            |::.:...|.||||.|||..|....|.:.
  Fly   203 FVSPVAQNDNSTSSRSSSIPPALAHLDSKMVDHILGESMHDFKPVAWEDIAGLESAKSTFLEAII 267

Human   495 YPVEHPDKFLKFGM-TPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEAN 558
            .|:..||.|.  |: .|.:|||.:||||.||||:||:||::.:|.|.||....|.:.|.|::|..
  Fly   268 MPLRRPDLFT--GVRCPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKL 330

Human   559 VREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKK--NVFIIG 621
            |:.:|..|....|.::|.||:||:...|..|..:   :..|:.|:.|..:||.::.:  .|.:||
  Fly   331 VKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENE---STLRLKNEFLIHLDGAASNEEIRVLVIG 392

Human   622 ATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLE---FLAKMTNGFS 683
            |||||..:|.|:.|  |..:.:|:|||..::|..|::..:.:  |..::|:.   .||::|:|:|
  Fly   393 ATNRPQELDEAVRR--RFVRRLYVPLPTREARQKIIEKLIHQ--VKHNLDVRQVIELAELTDGYS 453

Human   684 GADLTEICQRACKLAIRESIESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVS 748
            |||:..:|:.|....:             |...|..|||.|...:|.:..|.|::|:|...:|||
  Fly   454 GADVDTLCRYASMAPL-------------RSLTPDQMEVIETHQLPAVTMDDFKQALRVISKSVS 505

Human   749 DNDIRKYE 756
            ..|.:::|
  Fly   506 SEDCKQFE 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VCP	NP_009057.1	CDC48	25..764	CDD:273521	118/398 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..727		6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..806
		Interaction with UBXN6. /evidence=ECO:0000269\|PubMed:18656546	797..806
		PIM motif. /evidence=ECO:0000269\|PubMed:24726327	802..806
Fign	NP_001259995.1	AAA	282..418	CDD:214640	55/140 (39%)
		AAA	286..416	CDD:278434	51/134 (38%)
		Vps4_C	<480..520	CDD:286426	11/34 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810