DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VCP and Rpt6

DIOPT Version :9

Sequence 1:	NP_009057.1	Gene:	VCP / 7415	HGNCID:	12666	Length:	806	Species:	Homo sapiens
Sequence 2:	NP_608447.1	Gene:	Rpt6 / 33105	FlyBaseID:	FBgn0020369	Length:	405	Species:	Drosophila melanogaster

Alignment Length:	377	Identity:	129/377 - (34%)
Similarity:	210/377 - (55%)	Gaps:	24/377 - (6%)

- Green bases have known domain annotations that are detailed below.

Human   344 MAATNRPNSIDPALRRFGRFD-------REVDIGIPDATGRLEILQ-----IHTKNMKLADDVDL 396
            |..||| ..|:.|..:...|.       .|:.:.:.:....|..||     ::.|...|.:::.|
  Fly     1 MTVTNR-MEIESAYHKGEGFRSYYIQKIEELQLVVAEKHQNLRRLQAQRNELNAKVRMLREELQL 64

Human   397 EQVANETHGHVGADLAALCSEAALQAIRKK-MDLIDLEDETIDA-EVMNSLAVTMDDFRWALSQS 459
            .|   |...:||..:..:..:..|..:..: ..::|| |:.||. :|..:..|.:.:..:.|.:.
  Fly    65 LQ---EQGSYVGEVVKPMDKKKVLVKVHPEGKFVVDL-DKNIDINDVTPNCRVALRNESYTLHKI 125

Human   460 NPSALRETV----VE-VPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGP 519
            .|:.:...|    || ||..|:|.:|||:...:|::|:::.||:||:.|...|:...||||.|||
  Fly   126 LPNKVDPLVSLMMVEKVPDSTYEMVGGLDKQIKEIKEVIELPVKHPELFDALGIAQPKGVLLYGP 190

Human   520 PGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAK 584
            ||.||||||:|:|:..:..||.:.|.||:..:.||....|||:|..||:.||.::|.||:|||..
  Fly   191 PGTGKTLLARAVAHHTECTFIRVSGSELVQKFIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGS 255

Human   585 ARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPD 649
            :|..:...|.....|.:.::|.::||....||:.:|.||||.||:|||:|||||:|:.|..|.|:
  Fly   256 SRIESGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDPALLRPGRIDRKIEFPPPN 320

Human   650 EKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRE 701
            |::|:.|||.:.||..:.:.::|..:|::..|.|||::..:|..|...|:||
  Fly   321 EEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRE 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VCP	NP_009057.1	CDC48	25..764	CDD:273521	129/377 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..727
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..806
		Interaction with UBXN6. /evidence=ECO:0000269\|PubMed:18656546	797..806
		PIM motif. /evidence=ECO:0000269\|PubMed:24726327	802..806
Rpt6	NP_608447.1	RPT1	17..403	CDD:224143	123/360 (34%)
		SlyX	<27..>69	CDD:294687	9/44 (20%)
		AAA_16	152..>205	CDD:289934	27/52 (52%)
		AAA	185..317	CDD:278434	61/131 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910