DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VCP and Rpt3

DIOPT Version :9

Sequence 1:	NP_009057.1	Gene:	VCP / 7415	HGNCID:	12666	Length:	806	Species:	Homo sapiens
Sequence 2:	NP_001285108.1	Gene:	Rpt3 / 32047	FlyBaseID:	FBgn0028686	Length:	413	Species:	Drosophila melanogaster

Alignment Length:	420	Identity:	142/420 - (33%)
Similarity:	215/420 - (51%)	Gaps:	44/420 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    28 VDEAINEDNSVVSL----SQPKMDELQLFRGDTVLLKGKKRREAV-CIVLSDDTCSDEKIRMNRV 87
            :|..|.|.:.:..|    :...:|||.:   :.:.::.||.::.: .|.:.::...||:    |.
  Fly     5 MDVLIPEKDELSDLKLKDAHSSLDELDM---EDLYVRYKKLQKTLEFIEVQEEYIKDEQ----RN 62

Human    88 VRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITG-----NLFEVYLKPYFLEAYRPIR 147
            ::........:|..||..|.| .|:.:..:   |...||.|     |.:...|.....|..:|
  Fly    63 LKKEYLHAQEEVKRIQSVPLV-IGQFLEAV---DQNTGIVGSTTGSNYYVRILSTIDRELLKP-- 121

Human   148 KGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQ 212
            ...:.|.:.....|:....|.| |...::.||.      :|           :|.|.||||...|
  Fly   122 SASVALHKHSNALVDVLPPEAD-SSISMLQPDE------KP-----------DVSYADIGGMDMQ 168

Human   213 LAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSK 277
            ..:|:|.|||||.|..|:|.||:.||||:|:|||||.|||::|:|||:.|.|.|..:.|.|.:.|
  Fly   169 KQEIREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTASFIRVVGSEFVQK 233

Human   278 LAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVER---RIVSQLLTLMDGLKQRA 339
            ..||....:|..|..|::||||||||||:||||.||.......:|   ||:.:||..|||..|..
  Fly   234 YLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTT 298

Human   340 HVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETH 404
            :|.|:.||||.:::||||.|.||.||:::..:||...:..:....|..|.|::|||||:......
  Fly   299 NVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLVFSTITSKMNLSEDVDLEEFVARPD 363

Human   405 GHVGADLAALCSEAALQAIRKKMDLIDLED 434
            ...|||:.|:|.||.:.|:|:...::..:|
  Fly   364 KISGADINAICQEAGMHAVRENRYIVLAKD 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VCP	NP_009057.1	CDC48	25..764	CDD:273521	142/420 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..727
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..806
		Interaction with UBXN6. /evidence=ECO:0000269\|PubMed:18656546	797..806
		PIM motif. /evidence=ECO:0000269\|PubMed:24726327	802..806
Rpt3	NP_001285108.1	PTZ00454	22..413	CDD:240423	138/403 (34%)
Rpt3	NP_001285108.1	AAA	197..330	CDD:278434	64/132 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910