DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VCP and CG10793

DIOPT Version :9

Sequence 1:	NP_009057.1	Gene:	VCP / 7415	HGNCID:	12666	Length:	806	Species:	Homo sapiens
Sequence 2:	NP_570054.2	Gene:	CG10793 / 31308	FlyBaseID:	FBgn0029656	Length:	479	Species:	Drosophila melanogaster

Alignment Length:	291	Identity:	92/291 - (31%)
Similarity:	156/291 - (53%)	Gaps:	37/291 - (12%)

- Green bases have known domain annotations that are detailed below.

Human   187 EPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGK 251
            |.:|....:|:: ::.:.|:.|.::.:..|||.|..|:..|.|| |.|:||.|.:||:||||:||
  Fly   190 ELVKTSILQENI-KIKWSDVCGNQRAIELIKEAVLTPIEFPQLF-AHGLKPWRSLLLHGPPGSGK 252

Human   252 TLIARAVANET--GAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKRE 314
            ||:|:|:.:||  ...||.|....::||..||||..||..|..|.|.||::||.||::::..||:
  Fly   253 TLLAKALYSETQGQVTFFNITASIMVSKWRGESEKILRVLFHMAAKRAPSVIFFDEIESLTSKRD 317

Human   315 K-THGEVERRIVSQLLTLMDGLKQRAH-VIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGR 377
            : |..|..:|..::||.|:||::...: |.|:|:||.|..||.|..|  ||::::.:.:|:|..|
  Fly   318 RATDHESSKRFKNELLQLLDGMEHSLNGVFVLASTNLPWDIDEAFLR--RFEKKLLVQLPNAAER 380

Human   378 LEILQIHTKNMKLADDVD-----LEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETI 437
            ..::     |..|...:.     |||:...:....|.::...|.|.::..:|....:.|
  Fly   381 SCLI-----NRLLGSSISLNPRLLEQLVEISDHFTGDEIRLACKEISMHRVRCATKIGD------ 434

Human   438 DAEVMNSLAVTMDDFRWALSQSNPSALRETV 468
                 .|:.:        |::.:|:|:...|
  Fly   435 -----RSIGL--------LAKESPAAIEANV 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VCP	NP_009057.1	CDC48	25..764	CDD:273521	92/291 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..727
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..806
		Interaction with UBXN6. /evidence=ECO:0000269\|PubMed:18656546	797..806
		PIM motif. /evidence=ECO:0000269\|PubMed:24726327	802..806
CG10793	NP_570054.2	LisH	31..56	CDD:285685
		P-loop_NTPase	205..>259	CDD:304359	26/54 (48%)
		AAA	238..376	CDD:214640	58/139 (42%)
		AAA	242..374	CDD:278434	56/133 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910