DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VCP and CG31495

DIOPT Version :9

Sequence 1:	NP_009057.1	Gene:	VCP / 7415	HGNCID:	12666	Length:	806	Species:	Homo sapiens
Sequence 2:	NP_001287320.1	Gene:	CG31495 / 261626	FlyBaseID:	FBgn0051495	Length:	341	Species:	Drosophila melanogaster

Alignment Length:	329	Identity:	68/329 - (20%)
Similarity:	116/329 - (35%)	Gaps:	83/329 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   367 VDIGIPDATGRLEILQIHTK---NMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMD 428
            |:|.:|:...|:.:|:....   ::.:|.||...::|.:|......:|..|..||..:||.:
  Fly     2 VNITLPNTEERVNLLKSRINRLGDITVAGDVCAREIAMKTKNFTEDELCQLVREALHEAIVR--- 63

Human   429 LIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELV 493
                   |........|.||..|...|:....|...|:                   :..||.|:
  Fly    64 -------THVTRCPKGLQVTQVDLLAAVKIIQPRFGRQ-------------------EETLQLLM 102

Human   494 QYPVEH-------PDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFIS-IKGPELLTM 550
              |.|:       |:..|..|.......|..|.|..|.|.:|..:|.:....||. |...|||.:
  Fly   103 --PYEYLDRTAFDPNDLLSTGRPRWSCHLVEGKPKSGLTTVAAQMALKTDCPFIKYISSAELLGL 165

Human   551 WFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKK 615
            ...|....:||:.:.|..:....:..|:.:.:       || .|....|...:.|.::..:..|:
  Fly   166 SDSEKCQRIREVLEDAYVSRRSCVIIDDFERV-------IG-YGALGKRYSKEFLQKLTVLLKKQ 222

Human   616 -----NVFIIGATNRPDIID--------------PAILRPGRLDQLIYIPLPDEKSRVAILKANL 661
                 .:.||..:||.|:::              |.:..|              |..:.|::|:.
  Fly   223 PPNSHELIIICTSNRLDVLEELGLLSVFTSVHNVPNVSTP--------------KELMVIVEASK 273

Human   662 RKSP 665
            |..|
  Fly   274 RFEP 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VCP	NP_009057.1	CDC48	25..764	CDD:273521	68/329 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..727
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..806
		Interaction with UBXN6. /evidence=ECO:0000269\|PubMed:18656546	797..806
		PIM motif. /evidence=ECO:0000269\|PubMed:24726327	802..806
CG31495	NP_001287320.1	AAA	129..259	CDD:214640	30/137 (22%)
CG31495	NP_001287320.1	P-loop_NTPase	129..257	CDD:304359	29/135 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810