DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nuak2 and par-1

DIOPT Version :9

Sequence 1:	NP_001181954.1	Gene:	Nuak2 / 74137	MGIID:	1921387	Length:	639	Species:	Mus musculus
Sequence 2:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	651	Identity:	197/651 - (30%)
Similarity:	297/651 - (45%)	Gaps:	127/651 - (19%)

- Green bases have known domain annotations that are detailed below.

Mouse     6 LLQRPSQAPSASALASESARPLADGLIKSPKPLMKKQAVKRHHHKHNLRHRYEFLETLGKGTYGK 70
            :|...|..|||....:.||:...:..::|..| |:.:|.:.|..|      |:.::|:|||.:.|
  Fly   209 VLSTHSAHPSAIKQRTSSAKGSPNMQMRSSAP-MRWRATEEHIGK------YKLIKTIGKGNFAK 266

Mouse    71 VKKARE-SSGRLVAIKSIRKDKIKDEQDLLHIRREIEIMSSLNHPHIIAIHEVGRSRLVTVFENS 134
            ||.|:. .:|:.||||.|.|.:: :...|..:.||:.||..|:||:|:        :|..|.|..
  Fly   267 VKLAKHLPTGKEVAIKIIDKTQL-NPGSLQKLFREVRIMKMLDHPNIV--------KLFQVIETE 322

Mouse   135 SKIVIVMEYASRGDLYDYISERPRLSERDARHFFRQIVSALHYCHQNGIVHRDLKLENILLDANG 199
            ..:.::|||||.|:::||:....|:.|::||..|||||||:.||||..|:|||||.||:|||:..
  Fly   323 KTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSEL 387

Mouse   200 NIKIADFGLSNLYHKGKFLQTFCGSPLYASPEIVNGKPYVGPEVDSWSLGVLLYILVHGTMPFDG 264
            ||||||||.||.:..|..|.||||||.||:||:..||.|.|||||.|||||:||.||.|::||||
  Fly   388 NIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG 452

Mouse   265 QDHKTLVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTRRATLEDVASHWWVNWGYTTGVGEQEA 328
            ...:.|.:::..|.||.|...|..| .|:|..|::||.:||:||.:....|:|.|:     |::.
  Fly   453 STLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGF-----EEDE 512

Mouse   329 LREGGHPSGDFG------------------RASM---------ADWL---RRSSRPLLENGAKVC 363
            |:....|..|..                  .||:         |.:|   |:|:.|..:......
  Fly   513 LKPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLLGRKSTDPESDGSRSGS 577

Mouse   364 SFFKQHVPG-------GGSTVP-----GLERQ---HSLKKSRKEND------------MAQNLQG 401
            |...:::.|       |.::|.     |:.|.   .|.|.||:.:.            .|....|
  Fly   578 SLSLRNISGNDAGANAGSASVQSPTHRGVHRSISASSTKPSRRASSGVGPTNAAATVAAATGAVG 642

Mouse   402 --DPAEDTSSRPGKSSLKLPKGILKKKSSTSSGEVQED-----PQELRPVPDT------------ 447
              :|:.:.::....:.........|::::..|..::|:     .|..||...|
  Fly   643 AVNPSNNYNAAGSAADRASVGSNFKRQNTIDSATIKENTARLAAQNQRPASATQKMLTTADTTLN 707

Mouse   448 -PGQPVPAVSLLPRKGILKKS------RQRESGYYSSPEPSESGELLDASDVFVSGDPVEQKSPQ 505
             |.:|..|....|..|....|      .:|.:..|.....:|...::                |.
  Fly   708 SPAKPRTATKYDPTNGNRTVSGTSGIIPRRSTTLYEKTSSTEKTNVI----------------PA 756

Mouse   506 ASGLL--LHRKGILKLNGKFSRTALEGTTPSTFGSLDQLASSHPAARPSRPSGAVSEDSILSSES 568
            .:.|.  |.....:|.:..|.|..   .:.|||.|....|.::.|...|..|||..:.|.....|
  Fly   757 ETNLFDRLRMASAVKSSRHFPRNV---PSRSTFHSGQTRARNNTALEYSGTSGASGDSSHPGRMS 818

Mouse   569 F 569
            |
  Fly   819 F 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nuak2	NP_001181954.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		5/14 (36%)
		PKc_like	53..315	CDD:304357	122/263 (46%)
		S_TKc	57..315	CDD:214567	122/259 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..485		28/165 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..575		13/41 (32%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	123/266 (46%)
		S_TKc	253..504	CDD:214567	122/259 (47%)
		UBA_MARK_Par1	525..563	CDD:270522	4/37 (11%)
		MARK1-3_C	839..936	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910