DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VCAM1 and igdb-1

DIOPT Version :9

Sequence 1:	NP_001069.1	Gene:	VCAM1 / 7412	HGNCID:	12663	Length:	739	Species:	Homo sapiens
Sequence 2:	NP_502387.2	Gene:	igdb-1 / 3565301	WormBaseID:	WBGene00011418	Length:	1029	Species:	Caenorhabditis elegans

Alignment Length:	811	Identity:	149/811 - (18%)
Similarity:	270/811 - (33%)	Gaps:	261/811 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    44 SLTCSTTGCESPFFSW----------RTQIDSPLNGKVTNE------GTTSTLTMNPVSFGNEHS 92
            ::|.:|| |.:   .|          |...|..|...|.::      |:|..|.:        ||
Worm    13 TITIATT-CRA---EWPKVSPCIADGRNHTDCCLKKGVQHDCLEICSGSTKELGV--------HS 65

Human    93 YLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGP-------LEAGKPITVKCSV--ADVYPFDRL 148
            .||        |...:|.......:..|.|.|.|       |.| ..:||:.:.  ::.:..:..
Worm    66 VLC--------LNLDLQAIYQCIRQGYETHPSAPGNVTISELTA-HSVTVQWTEPNSNAHLVENY 121

Human   149 EIDLLKGDHLMKSQEFLEDADR--KSLETKSLEVTFTPVIEDI---------GKVLVCRAKLHID 202
            .:.:.|.:|        .:|.|  |::.:..:|:...|..|.:         |..|...|||
Worm   122 TLFIRKNEH--------GEAVRTVKNVISPHVELGLDPDSEYVLTLQSHSANGTSLPSTAKL--- 175

Human   203 EMDSVPTVRQAVKEL--QVYISPKNTVI--SVNPSTK----LQEGGSVTMTCSSEGLPAPEIFWS 259
             ..::||.|..:..:  .:|::....:|  :|||...    ...|..::..|..:|..:.|.|.|
Worm   176 -FSTLPTTRPPLCTIGEPIYMNDGRVMICDAVNPCPNGFRCTGAGSDLSYCCPHDGTHSSEEFTS 239

Human   260 ----KKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEK--------- 311
                :|:....:.....|.||.      |.....:...|....:....:...:||:
Worm   240 CCKEQKMPESCMSSCQYNMTLP------ESCKENLNTWVQCASEGHDHLRCCLQEEVSKPCQTAC 298

Human   312 --PFTVEISPGPRIAAQIGDSVMLTC-----------------SVMGCESPSFSW---------- 347
              ||||   |.....:::  |...||                 |.:..:|.:.||
Worm   299 MHPFTV---PADECFSEV--SKYRTCFSAAHQALPAAVRNVEVSSISKDSATISWEDLEANIIVF 358

Human   348 RTQIDSPLSGKVRSEGTNS--------------TLTLSPVSF--ENEHSYLCTVTCGHKKLEKG- 395
            |.|:.......:::|.:::              ::.::.::|  |...|:..|.|....::.:|
Worm   359 RVQLFEKGGNLIKTENSSADIFRFIDLEPNKDYSVRVTAINFLGEGPPSWNATFTTKPAQIYEGD 423

Human   396 -------IQVELYSFPR-----DPEIEMSGGLVNGSSVTVSCKV---PSVYPLDRLEIELLKGET 445
                   :::...|.||     ||           .||..:.:|   |..|.:..|:.|.....|
Worm   424 RPVAPEKLRISWNSGPRVNVTWDP-----------VSVRRNAEVVTKPIEYTIYYLDTEQSSTWT 477

Human   446 ILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNV- 509
            .|...:..  ..|:.|...:|...::...||                     .|.|..:..:.:
Worm   478 TLRTNQTW--VVMRDLRKDALYYVYVTAKED---------------------NRTSRSSSIITIL 519

Human   510 APRDTTVLVSPSSILE---------EGSSVNMTCLSQGFPAPKILWSRQLPN------------G 553
            |.:|:..|..|:.::|         .|..:::.|              .|||            .
Worm   520 AQKDSPGLPEPTIVIEPDHKDGVFSPGEKISINC--------------SLPNIKKHLNIDLTVGS 570

Human   554 ELQPLSENATLTLISTKMEDS-GVYLCEGINQAGRSRKEVELII-----QVTPKDIKLTAFPSES 612
            .:......|...::.|:.::: ....|...:..||....::.::     .||.|..|:.....:|
Worm   571 HVVQNDHGALWVILETEADEAMDTATCAVSDTDGRQHVAMKHLVLERKASVTMKKDKIRVLDDQS 635

Human   613 VKEGDTVIISCTC--GNVPETWIILK--KKAETGDTVLKSIDGAYT----IRKAQLKDAGVYECE 669
            |:      |.|..  |.:.......|  |||..|...||..:..|.    |||.:.:|||.|:|.
Worm   636 VE------IECIYRGGGLDPKISFEKDGKKASRGFLNLKKTEAGYVAKWHIRKVKQEDAGFYKCV 694

Human   670 SKNKVGSQLRSLTLDVQGRENNKDYFSPELL 700
            ..:..||::.:         :::..||.|.|
Worm   695 VTSSDGSRVEA---------SSEVIFSTETL 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VCAM1	NP_001069.1	IG	33..112	CDD:214652	18/83 (22%)
		Ig_VCAM-1	116..214	CDD:143313	24/117 (21%)
		IGc2	238..298	CDD:197706	12/63 (19%)
		I-set	313..399	CDD:333254	20/136 (15%)
		Ig_VCAM-1	404..502	CDD:143313	19/105 (18%)
		IG_like	519..596	CDD:214653	12/98 (12%)
		IG	609..685	CDD:214652	23/83 (28%)
igdb-1	NP_502387.2	DB	1..80	CDD:279948	18/86 (21%)
		FN3	88..178	CDD:238020	19/102 (19%)
		Lustrin_cystein	187..227	CDD:291299	6/39 (15%)
		DB	240..321	CDD:279948	16/91 (18%)
		FN3	328..414	CDD:238020	11/85 (13%)
		FN3	425..518	CDD:238020	21/126 (17%)
		ig	628..701	CDD:278476	21/78 (27%)
		DB	726..809	CDD:279948
		FN3	818..895	CDD:214495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161463478
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930