DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment VCAM1 and ed

DIOPT Version :9

Sequence 1:NP_001069.1 Gene:VCAM1 / 7412 HGNCID:12663 Length:739 Species:Homo sapiens
Sequence 2:NP_001260013.1 Gene:ed / 33619 FlyBaseID:FBgn0000547 Length:1332 Species:Drosophila melanogaster


Alignment Length:628 Identity:143/628 - (22%)
Similarity:246/628 - (39%) Gaps:137/628 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    43 VSLTCSTT-GCESPFFSW-RTQIDSP-----LNGKVTNEGTTSTLTMNPVSFGNEHSYLCT---- 96
            :.||||:. |...|..:| |...::|     |.|...::.|.:||::.|....:...|.|.    
  Fly   169 MELTCSSIGGSPDPTITWYREGSNTPLPATVLKGGTKDQPTNATLSIIPRREDDGAKYKCVVRNR 233

Human    97 ATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVK--CSVADVYPFDRLEIDLLKGDHLM 159
            |..|.::||....:.:..:|: .|:....||...:..|.|  |:| |..|    ::..::.:   
  Fly   234 AMNEGKRLEATATLNV
NYYPR-VEVGPENPLRVERDRTAKLECNV-DAKP----KVPNVRWN--- 289

Human   160 KSQEFLEDADRKSLETKSLEVTFTPV-IEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISP 223
            ::..|:         :.||..|...| ::|.|| ..|.|...:.        :...:||.:.|..
  Fly   290 RNGRFI---------SSSLVHTIHRVSVQDAGK-YTCIADNGLG--------KTGEQELILDILY 336

Human   224 KNTVISVNPSTKLQEGGSVTMTCSSEGLPAP-EIFWSKKLD-----NGNLQHLSGNATLTLIAMR 282
            ...|:..:.:.:.:||.:||:.|:....||| .|.|.|:..     ||::        |||.::|
  Fly   337 PPMVVIESKTREAEEGDTVTIRCNVTANPAPVTIEWLKENSPDFRYNGDV--------LTLTSVR 393

Human   283 MEDSGIYVCEGVNLI---GKNRKE------VELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSV- 337
            .:.:|.|:|..||::   |..|.|      |.|:|:.:|....|:|...: ..:|:.|.||||. 
  Fly   394 ADHAGNYICRAVNIMQSQGMERSERVGNSTVALLVRHRPGQAYITPNKPV-VHVGNGVTLTCSAN 457

Human   338 -MGCESPSFSWRTQIDSPLSG--KVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKG---- 395
             .|...|.:.|...:|...|.  |:.::|...::..:.:.  ||..|.|     |...|.|    
  Fly   458 PPGWPVPQYRWFRDMDGEFSSTQKILAQGPQYSIPKAHLG--NEGKYHC-----HAVNELGIGMM 515

Human   396 --IQVELYSFPR---DPEIEMSGGLVNGSSVTVSCK-----VPSVYPLDRLEIELLKGETILENI 450
              |.:|::..|:   ..:..|:..:.: :..||:|.     .|||..| :..:|:|..|.:.| :
  Fly   516 ATIVLEIHQPPQFLAKLQQHMTRRVAD-TDYTVTCSAKGKPAPSVKWL-KDAVEILPEENLYE-V 577

Human   451 EFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLY---VNVAPR 512
            :...|..:..:.....::.|.......|.|||             |..|.....||   ||.|..
  Fly   578 QTNPDQGLNGMVTVQSQLKFRGKARPNGNALV-------------PGDRGLYTCLYQNEVNSANS 629

Human   513 DTTVLVSPSSIL---------EEGSSVNMTCLSQGFPAPKILWSRQLPNG------------ELQ 556
            ...:.:....|:         :...:..:.|..|.:|.|:..|  |..|.            |:.
  Fly   630 SMQLRIEHEPIVLHQYNKVAFDIRETAEVVCKVQAYPKPEFQW--QFGNNPSPLTMSSDGHYEIS 692

Human   557 PLSEN-----ATLTLISTKMEDSGVYLCEGINQAGRSRKEVEL 594
            ..::|     :.|.:.|....|.|.|.|...|.....|..:.|
  Fly   693 TTTDNNDIYTSVLKINSLTHSDYGEYTCRVANTLDTIRAPIRL 735

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VCAM1NP_001069.1 IG 33..112 CDD:214652 21/79 (27%)
Ig_VCAM-1 116..214 CDD:143313 20/100 (20%)
IGc2 238..298 CDD:197706 22/68 (32%)
I-set 313..399 CDD:333254 23/95 (24%)
Ig_VCAM-1 404..502 CDD:143313 21/105 (20%)
IG_like 519..596 CDD:214653 19/102 (19%)
IG 609..685 CDD:214652
edNP_001260013.1 Ig 50..147 CDD:299845
I-set 146..249 CDD:254352 21/79 (27%)
Ig 168..249 CDD:299845 21/79 (27%)
IGc2 268..323 CDD:197706 16/72 (22%)
Ig_3 341..406 CDD:290638 20/72 (28%)
Ig_2 437..514 CDD:290606 22/84 (26%)
I-set 526..633 CDD:254352 26/122 (21%)
Ig 546..632 CDD:143165 24/100 (24%)
IG_like 654..736 CDD:214653 18/84 (21%)
Ig 656..734 CDD:143165 17/79 (22%)
FN3 741..848 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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