DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VCAM1 and DIP-lambda

DIOPT Version :9

Sequence 1:	NP_001069.1	Gene:	VCAM1 / 7412	HGNCID:	12663	Length:	739	Species:	Homo sapiens
Sequence 2:	NP_001334747.1	Gene:	DIP-lambda / 26067049	FlyBaseID:	FBgn0267428	Length:	548	Species:	Drosophila melanogaster

Alignment Length:	384	Identity:	88/384 - (22%)
Similarity:	145/384 - (37%)	Gaps:	65/384 - (16%)

- Green bases have known domain annotations that are detailed below.

Human   261 KLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGV-NLIGKNRKEVELIVQEKPFTVEISPGPRIA 324
            |:.||.|       ..::..:.::...|..|..| ::.||...| |:   :..|..::|   ...
  Fly    10 KMYNGTL-------ACSIAFILIKAITITKCHAVAHIHGKGESE-EI---DPQFLAKLS---NTT 60

Human   325 AQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSG------------KVRSEGTNS-TLTLSPVSFE 376
            ..||..:..||.|........:|.......:.|            .|...|.|: .|.:|.|...
  Fly    61 VPIGRDISFTCVVDNLGHYRVAWIKSDSKAILGIHTHMVSLNPRLSVTHNGHNTWKLHISRVQIN 125

Human   377 NEHSYLCTVTCGHKK-----LEKGIQVELYSFP-RDPEIEMSGGLVNGSSVTVSCKVPSVYPLDR 435
            :..||:|.|.....|     |:..:..::.:.| .:||   .|....|.|:::.|.|..| |..:
  Fly   126 DSGSYMCQVNTDPMKSLSGYLDVVVPPDILNHPEHNPE---DGVCQEGGSISLMCSVTGV-PRPK 186

Human   436 LEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQ 500
            :......|:.|:...:..:.|..||:|.:.|.:|.:.. .|.| ...|.|...|      |....
  Fly   187 VLWRREAGKEIILRTDGRDKTGFKSVEGERLVLTNVQR-SDMG-GYNCIASNGI------PPSVS 243

Human   501 STQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSR-----QLPNGELQPLSE 560
            ....:|||.:|....:.....:.:|.  .|.:.|:.:.||.|...|.|     :|.||....:||
  Fly   244 KRFNVYVNFSPTVKAISQLVGAPVER--EVTLECIVEVFPKPLNGWYRSEGNIKLHNGNKYNISE 306

Human   561 --------NATLTLISTKMEDSGVYLCEGINQAGRSRKEVEL-IIQVTPKDIKLTAFPS 610
                    :..||:......|.|.|.|..:|..|:|...:.| .:::.|   |||..|:
  Fly   307 EVINIYTWHLNLTIRHLTKSDFGTYSCSSVNALGKSESLIRLQELRLPP---KLTTTPT 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VCAM1	NP_001069.1	IG	33..112	CDD:214652
		Ig_VCAM-1	116..214	CDD:143313
		IGc2	238..298	CDD:197706	7/37 (19%)
		I-set	313..399	CDD:333254	21/103 (20%)
		Ig_VCAM-1	404..502	CDD:143313	24/98 (24%)
		IG_like	519..596	CDD:214653	23/90 (26%)
		IG	609..685	CDD:214652	1/2 (50%)
DIP-lambda	NP_001334747.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910