DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VCAM1 and unc-52

DIOPT Version :9

Sequence 1:	NP_001069.1	Gene:	VCAM1 / 7412	HGNCID:	12663	Length:	739	Species:	Homo sapiens
Sequence 2:	NP_001364664.1	Gene:	unc-52 / 175126	WormBaseID:	WBGene00006787	Length:	4075	Species:	Caenorhabditis elegans

Alignment Length:	734	Identity:	162/734 - (22%)
Similarity:	258/734 - (35%)	Gaps:	190/734 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    40 GDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHS-----YLCTAT- 98
            |:.....|.|||..:|..:|.....|||...||      .|..|.:.|.|..|     |.|||:
Worm  2600 GERHQFRCITTGSPTPKITWTGPNGSPLPHDVT------PLEPNILDFSNGRSELNGDYTCTASN 2658

Human    99 -----CESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSV----ADVYPFDRLEIDLLK 154
                 .:...:..|..:.:.:.|..|::.::    .|:|:.|||..    .|..|    |:
Worm  2659 PIGEASDHGNVNIGPSLTVKTNPPGPKLIVT----VGEPLQVKCEAFGAPGDPEP----EV---- 2711

Human   155 GDHLMKSQEFLEDADRKSLETKSLEVTFTPVI--------EDIG----KVLVCR-AKLHIDEMDS 206
                    |:|.|   ...|...|...|.||.        .::|    .|..|: :..|
Worm  2712 --------EWLHD---PGPERGDLPDDFKPVTISEQFIRHPNVGLGNAGVYTCKGSSAH------ 2759

Human   207 VPTVRQAVKELQVYISPKNTVISVN----PSTKLQEGGSVTMTCSSEGLP-APEIFWSKKLDN-- 264
                ..|.|.:.:.:...:.:.:|:    .|....:|....:.|::.|.. ...:.|.|..|.
Worm  2760 ----ATATKNIYIEVVEPSRIATVSILGGSSQWFDQGEKGELICTATGSSLVDRLEWEKVDDQLP 2820

Human   265 GNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELI------------VQEKPFTVEI 317
            .:::..:....|...:.:...:|.|.|.|.       :..|:|            ..::| .|||
Worm  2821 TDVEEHNEPGLLHFPSFKNSYAGEYRCNGY-------RNNEIIASAAVHVHSSANADDEP-KVEI 2877

Human   318 SPGPRI-AAQIGDSVMLTCSVMGCES-PSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHS 380
            .| ||: ....||:::|.|||.|.|: ..|.|.......|   ||..||..||.::.....|:..
Worm  2878 EP-PRVRVVSQGDNIVLKCSVQGAENGEHFKWALLRGGSL---VRQLGTEPTLEITKADPSNDFG 2938

Human   381 -YLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGE 444
             |.|.|                        |.:.|||.||:.|    ..||...|:...:::|
Worm  2939 VYRCNV------------------------EDNNGLVIGSAFT----AVSVGQQDKSHAQIVK-- 2973

Human   445 TILENIEFLEDTDMK---------------SLENKSLEMTFIPT-----IEDTGKALVCQAKLHI 489
                   |.:.:|..               :.||..|....:|.     |::...|   .|..::
Worm  2974 -------FDDKSDASFTCPIYSVPGSKVDWTYENGDLPSKAVPNGNKIEIKEFDDA---SAGTYV 3028

Human   490 DDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEE-GSSVNMTCLSQGFPAPKILWSRQLPNG 553
            ..:.|:....:...|..:.|......||:..||...: |......|...|.|:..|.|::: .|.
Worm  3029 CKVSFDGNVVEGFVTAQMFVPDTIIQVLLEVSSESPQIGDRAWFDCKVTGDPSAVISWTKE-GND 3092

Human   554 ELQPLSENATLT---LIST--KMEDSGVYLCEGINQAGRSRKEVELIIQVTPKD-IKLTAFPSES 612
            :|.|   ||.:|   |:.|  |.:::|||.|....:||..:....|.:....:| :..|...|..
Worm  3093 DLPP---NAQVTGGRLLFTDLKEDNAGVYRCVAKTKAGPLQTRTVLNVGSGKQDQVTFTVADSLP 3154

Human   613 V--KEGDTVIISC-----TCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECE- 669
            |  ..|....:||     |..|....|...:....:|..|.:   |...:......|.|.|.||
Worm  3155 VVYTVGQPAYLSCIGKTETKPNQSVVWTKEEGDLPSGSRVEQ---GVLMLPSVHRDDEGSYTCEI 3216

Human   670 --SKNKVGSQLRSLTLDVQ 686
              .:|.|.|     |:|:|
Worm  3217 VKEENPVFS-----TVDLQ 3230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VCAM1	NP_001069.1	IG	33..112	CDD:214652	22/82 (27%)
		Ig_VCAM-1	116..214	CDD:143313	22/114 (19%)
		IGc2	238..298	CDD:197706	11/62 (18%)
		I-set	313..399	CDD:333254	27/88 (31%)
		Ig_VCAM-1	404..502	CDD:143313	21/117 (18%)
		IG_like	519..596	CDD:214653	24/82 (29%)
		IG	609..685	CDD:214652	20/85 (24%)
unc-52	NP_001364664.1	LDLa	125..156	CDD:238060
		IG	<193..264	CDD:214652
		LDLa	275..309	CDD:238060
		LDLa	314..349	CDD:238060
		LDLa	416..450	CDD:238060
		LDLa	498..535	CDD:238060
		LDLa	564..599	CDD:238060
		LDLa	752..786	CDD:238060
		IgI_Perlecan_like	834..919	CDD:409412
		Ig strand B	851..855	CDD:409412
		Ig strand C	867..871	CDD:409412
		Ig strand E	886..890	CDD:409412
		Ig strand F	900..905	CDD:409412
		Ig strand G	913..916	CDD:409412
		Ldl_recept_a	937..972	CDD:395011
		LDLa	977..1013	CDD:412164
		Ldl_recept_a	1020..1057	CDD:395011
		Ig_Perlecan_like	1075..1152	CDD:143220
		Ig strand B	1078..1082	CDD:143220
		Ig strand C	1091..1095	CDD:143220
		Ig strand E	1116..1120	CDD:143220
		Ig strand F	1130..1135	CDD:143220
		Ig strand G	1144..1147	CDD:143220
		EGF_Lam	1172..1218	CDD:214543
		LamB	1286..1413	CDD:214597
		Laminin_EGF	<1477..1511	CDD:395007
		LamB	1578..1702	CDD:214597
		Laminin_EGF	1748..1795	CDD:395007
		Laminin_EGF	1804..1851	CDD:395007
		IG	1932..2012	CDD:214652
		IG_like	2023..2104	CDD:214653
		Ig strand A'	2025..2029	CDD:409353
		Ig strand B	2032..2042	CDD:409353
		Ig strand C	2047..2054	CDD:409353
		Ig strand C'	2055..2058	CDD:409353
		Ig strand E	2067..2073	CDD:409353
		Ig strand F	2080..2088	CDD:409353
		Ig	2118..>2181	CDD:416386
		Ig strand A'	2122..2126	CDD:409353
		Ig strand B	2129..2139	CDD:409353
		Ig strand C	2144..2151	CDD:409353
		Ig strand C'	2152..2155	CDD:409353
		Ig strand E	2163..2170	CDD:409353
		IG	2212..2293	CDD:214652
		IG	2303..2383	CDD:214652
		IG_like	2404..2486	CDD:214653
		Ig strand A'	2406..2409	CDD:409353
		Ig strand B	2413..2423	CDD:409353
		Ig strand C	2430..2434	CDD:409353
		Ig strand C'	2436..2438	CDD:409353
		Ig strand D	2444..2449	CDD:409353
		Ig strand E	2450..2456	CDD:409353
		Ig strand F	2463..2470	CDD:409353
		IG	2499..2579	CDD:214652
		Ig	2598..2671	CDD:416386	21/76 (28%)
		Ig strand B	2601..2610	CDD:409353	1/8 (13%)
		Ig strand C	2615..2622	CDD:409353	2/6 (33%)
		Ig strand C'	2624..2627	CDD:409353	1/2 (50%)
		Ig strand F	2650..2658	CDD:409353	4/7 (57%)
		Ig strand G	2661..2671	CDD:409353	0/9 (0%)
		Ig_3	2673..2756	CDD:404760	21/105 (20%)
		Ig strand B	2694..2698	CDD:409353	1/3 (33%)
		Ig strand C	2710..2713	CDD:409353	1/14 (7%)
		Ig strand E	2736..2740	CDD:409353	0/3 (0%)
Ig strand F	2750..2755	CDD:409353	2/4 (50%)
Ig strand G	2763..2766	CDD:409353	1/2 (50%)
IG	2880..2955	CDD:214652	28/101 (28%)
Ig	2970..3043	CDD:416386	11/84 (13%)
Ig strand A'	2971..2974	CDD:409353	1/11 (9%)
Ig strand B	2978..2987	CDD:409353	1/8 (13%)
Ig strand C	2993..2997	CDD:409353	0/3 (0%)
Ig strand C'	2999..3001	CDD:409353	1/1 (100%)
Ig strand D	3006..3011	CDD:409353	1/4 (25%)
Ig strand E	3012..3018	CDD:409353	1/5 (20%)
Ig strand F	3025..3033	CDD:409353	0/7 (0%)
Ig strand G	3036..3043	CDD:409353	0/6 (0%)
Ig	3067..3137	CDD:416386	22/73 (30%)
Ig strand B	3070..3077	CDD:409353	1/6 (17%)
Ig strand C	3083..3088	CDD:409353	2/4 (50%)
Ig strand D	3097..3101	CDD:409353	2/3 (67%)
Ig strand E	3103..3107	CDD:409353	1/3 (33%)
Ig strand F	3116..3124	CDD:409353	4/7 (57%)
Ig strand G	3127..3137	CDD:409353	2/9 (22%)
IG	3154..3231	CDD:214652	21/85 (25%)
LamG	3257..3394	CDD:214598
EGF_CA	3411..3448	CDD:238011
LamG	3513..3644	CDD:214598
LamG	3882..4040	CDD:238058
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910