DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment VAV1 and sif

DIOPT Version :10

Sequence 1:NP_005419.2 Gene:VAV1 / 7409 HGNCID:12657 Length:845 Species:Homo sapiens
Sequence 2:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster


Alignment Length:937 Identity:185/937 - (19%)
Similarity:316/937 - (33%) Gaps:317/937 - (33%)


- Green bases have known domain annotations that are detailed below.


Human   155 EDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPP--KMTEYDKRCCCLREIQQTEEKYTDTLGSIQ 217
            |.|:|....|.|..:..............::.|  ::|:.:|....:.|:..||..|...|.::.
  Fly  1414 EIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLL 1478

Human   218 QHFLKPLQR--FLKPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGAANLYQ------------ 268
            :|:|:|::|  ||...:|..:|.||.:::.....||:.::|:|......|.::            
  Fly  1479 EHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAI 1543

Human   269 --VFIKYKERFLVYGRYCSQVESASK--------H-LDRVAAAREDVQMKLEECSQRANNGRFTL 322
              .|:.|...|.:|..:|:....|.|        | |....|||...|       |.::    ||
  Fly  1544 GSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQ-------QHSS----TL 1597

Human   323 RDLLMVPMQRVLKYHLLLQELVKHTQ-EAMEKENLRLALDAMRDLAQCVNEVKRDNETLRQI--- 383
            ...|:.|:||:|||.||||::...|. .|.|..:|..||..|..:|:.:||::|.:|....|   
  Fly  1598 ESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDH 1662

Human   384 --TNFQLSIEN-LDQS---LAHYGRPKIDGELKIT----SVERRSKMDRYAFLLDKALL-ICKRR 437
              ...|.|.:. :|.|   |.:||..:   .|.|:    .:::..::....|:...|:: :||.|
  Fly  1663 LFRQHQKSCKQPIDLSPGDLLYYGGVE---WLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKER 1724

Human   438 --------GDS------------YDLKDFVNLHSFQVRDDSSGDRDN-------------KKWSH 469
                    |.|            |.:  .:.:...|||..|:.|.|:             ::.|.
  Fly  1725 LRQKKKLMGVSSKNATNEVEIIRYQV--LIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSE 1787

Human   470 MFLLIEDQGAQGYELFFKT-RELKKKWMEQFEMAISNIYPENATANGHDFQ-MFSF--------- 523
            ...::.:..|.....|.|| |::.::.:....:.:.|....:.:.:||..| |.|.         
  Fly  1788 KVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTL 1852

Human   524 ----EETTSCKACQMLLRGTFYQGYRCHRC------RASAHKECLGRVPPCG--------RHGQD 570
                ::.|.......|.:.....|.:.|..      ..|..:|.....|..|        .|||.
  Fly  1853 ERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHYASGHTHGQQ 1917

Human   571 -----FPG-----------TMKKDKLHRRAQDKKRNELGLPKMEVFQEYYG-----------LPP 608
                 |.|           |....:.|::.|.:::.:     .::.|:.:.           .||
  Fly  1918 MQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQ-----QQLMQQGHAHAHPHPHPHPREPP 1977

Human   609 PPGAIGPFLRLNPGDIVEL---TKAEAEQNWWEG-----------------RNTSTNEIG----- 648
            ||....|.|..:..||..:   ||:|.|::..:|                 ..|||..:|     
  Fly  1978 PPPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPKATLGRTPNHLTLSTTSTLSVGSTGSQ 2042

Human   649 ------------WFPC------------------------------------------------- 652
                        :.|.                                                 
  Fly  2043 ARLIQSSHPPASYQPVLMKDLGKPSPDESELESESEVHAAQVAASFNLSLGSSGSLFASDARDNQ 2107

Human   653 --NRVKPYVH----------------GPPQDLSVHLWYAGPMERAGAESILA---------NRSD 690
              :|.:..:|                .|.||:.|...:....||..|...:|         .|..
  Fly  2108 TQSRTQSQIHSLHPSPRQSPRQSPRQSPKQDIEVIEIFESEAERLAASQQVAVVHQHPSDQARES 2172

Human   691 GTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRIT----------EKKAF--RGLTELVE 743
            |....|.|.::..|...:.::  ..||:..:..|.|...|          .:|||  :.|.|...
  Fly  2173 GHKQRRDRDRNPTETDATARF--MDKHLSDLEQENLTDGTCDIVAYMESLREKAFDPQDLAEDTG 2235

Human   744 FYQQNSLKDCFKSLDTTLQFPFKEPEKRTI---------------SRPA-----VGSTKYFGTAK 788
            .:|||         |::|     .||.:||               ||||     .|:|.  |.::
  Fly  2236 DHQQN---------DSSL-----SPEPQTIVENTQQTVVVDIESPSRPATESDSTGNTT--GPSE 2284

Human   789 ARYDFCARDRSELSLKEGDIIKILNKK 815
            ...|....:.:..||  ...|.:::||
  Fly  2285 RSGDETEEEATTSSL--ASHIVVIDKK 2309

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VAV1NP_005419.2 CH_VAV1 2..121 CDD:409111
RhoGEF 195..371 CDD:238091 55/201 (27%)
PH_Vav 385..508 CDD:269930 30/165 (18%)
C1_VAV1 510..566 CDD:410417 13/83 (16%)
SH3_VAV1_1 596..658 CDD:212912 20/160 (13%)
SH2_Vav1 665..767 CDD:198268 26/122 (21%)
SH3_VAV1_2 786..839 CDD:212909 6/30 (20%)
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
Tiam_CC_Ex 999..1096 CDD:408184
RBD 1141..1207 CDD:128731
PDZ 1220..1299 CDD:214570
RhoGEF 1456..1647 CDD:238091 55/201 (27%)
PH2_Tiam1_2 1650..1823 CDD:269957 32/177 (18%)
PHA03307 2227..>2510 CDD:223039 24/101 (24%)
Blue background indicates that the domain is not in the aligned region.

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