DRSC/TRiP Functional Genomics Resources

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Protein Alignment VAV1 and RtGEF

DIOPT Version :10

Sequence 1:NP_005419.2 Gene:VAV1 / 7409 HGNCID:12657 Length:845 Species:Homo sapiens
Sequence 2:NP_001097184.2 Gene:RtGEF / 35306 FlyBaseID:FBgn0015803 Length:1310 Species:Drosophila melanogaster


Alignment Length:372 Identity:75/372 - (20%)
Similarity:140/372 - (37%) Gaps:62/372 - (16%)


- Green bases have known domain annotations that are detailed below.


Human   142 YSGLSDQIDDTVEEDEDLYDCVENEEA---EG--------------DEIYEDLMRSEPVSMPPKM 189
            ||.:....|:...:..|:....:.|:.   ||              :|....|..:|.:..|.::
  Fly    11 YSFMGSNNDELCFQKGDVITVTQREDGGWWEGTLNDKTGWFPSNYVNECKVQLPLTETIRPPEEI 75

Human   190 TEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQ--RFLKPQDIEIIFINIEDLLRVHTHFLK 252
            .||  |...|:::..:|..:...|..:.::||:|:|  :.|...:...:..|..:::|.|...|.
  Fly    76 QEY--RSVVLKDLLDSERAHVAELQGLLENFLEPMQQTQILSQDEYAQLMCNFVEIVRTHEDLLI 138

Human   253 EMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRANN 317
            :::|.....|...|....:..|    |:..||:....|...||:.    :|...|..|....|..
  Fly   139 QIEECNDRVGKLFLTSAPLMKK----VHQAYCAAHPKAIVILDKY----KDELEKYMERQGAATP 195

Human   318 GRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA-MEKENLRLALDAMRDLAQCVNEVKRDNETLR 381
            |...|...|..|.:|:.||..:||||.:|.:.: .::.:.:.::...:|:|...:..:|..|...
  Fly   196 GLLVLTTGLSKPFRRLDKYSAMLQELERHMESSHPDRGDTQRSVAVYKDIAATCSATRRQKELEL 260

Human   382 QITNFQL------SIENLDQSLAHYGRPKIDGE------------LKITSVERRSKMDRYAFLLD 428
            |:....:      .:..|. .:.|.|...:..:            |...||.:|.....|...|.
  Fly   261 QVLTGPVRGWQGQELSTLG-DIIHMGSVAVGADHRDRYFVLFPQTLLFLSVSQRMSAFIYEGKLP 324

Human   429 KALLICKRRGDSYDLKDFVNLHSFQVRDD--------SSGDRDNKKW 467
            ...:|..|..|:..||     ::|::...        ..|..:..||
  Fly   325 LTGIIVNRLEDTDALK-----NAFEISSPLIDRIVAVCQGPNEANKW 366

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VAV1NP_005419.2 CH_VAV1 2..121 CDD:409111
RhoGEF 195..371 CDD:238091 41/178 (23%)
PH_Vav 385..508 CDD:269930 18/109 (17%)
C1_VAV1 510..566 CDD:410417
SH3_VAV1_1 596..658 CDD:212912
SH2_Vav1 665..767 CDD:198268
SH3_VAV1_2 786..839 CDD:212909
RtGEFNP_001097184.2 SH3_PIX 6..58 CDD:212810 7/46 (15%)
RhoGEF 79..249 CDD:238091 41/177 (23%)
PH_Cool_Pix 281..376 CDD:269932 17/91 (19%)
Blue background indicates that the domain is not in the aligned region.

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