Protein Alignment VAV1 and mug10

DIOPT Version :10

• Sequence 1: NP_005419.2
• Gene: VAV1 / 7409
• HGNCID: 12657
• Length: 845
• Species: Homo sapiens
• Sequence 2: NP_593309.2
• Gene: mug10 / 2541637
• PomBaseID: SPAC57A10.04
• Length: 344
• Species: Schizosaccharomyces pombe
• Alignment Length: 294
• Identity: 59/294 - (20%)
• Similarity: 115/294 - (39%)
• Gaps: 73/294 - (24%)

Human   178 MRSEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINI-- 240
            :.::.|...| .||::.   .|:||..||..|:..|.......:.|::    .|.:|...|.|
pombe    36 LEAKAVEQTP-ATEFNS---ILQEIISTEYNYSVDLKKTLNEIIMPIE----GQSMEREAIGICT 92

Human   241 --EDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAARED 303
              :.|.::||...::|..: |:| ..:|.|....:::   ||..|...:...|        |.|.
pombe    93 CFKTLNQLHTKLYQQMISS-GSP-VYSLSQSLPAFRD---VYHMYTINLSGIS--------AIEK 144

Human   304 VQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQE-AMEKENLRLA---LDAMR 364
            :......|:.:           |::|:|.:|:|.:.|..:.|..:: .....:.|:|   ||..|
pombe   145 IISDPSSCNSQ-----------LLIPLQHLLRYPIHLARVCKMLRKYPFLNGDFRMAVKTLDDFR 198

Human   365 DLAQCVNEVKRDNETLRQIT----------------NFQLSI-------------ENLDQSLAHY 400
            :|...:::.|...|:.:.::                .|:.|:             ...|..|..:
pombe   199 ELCSYIDQEKAREESYQVLSALCGNQGVAVDIPRHIKFKGSVIPATSFIYDFNACVFCDDGLVVW 263

Human   401 GRPKIDGELKITSVERRSKMDRYAFLLDKALLIC 434
            .|.....|:|..|:|:..::|.    |..::|:|
pombe   264 TRYVKKIEMKAVSIEQCLRVDE----LSNSILVC 293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VAV1	NP_005419.2	CH_VAV1	2..121	CDD:409111
		RhoGEF	195..371	CDD:238091	40/183 (22%)
		PH_Vav	385..508	CDD:269930	13/63 (21%)
		C1_VAV1	510..566	CDD:410417
		SH3_VAV1_1	596..658	CDD:212912
		SH2_Vav1	665..767	CDD:198268
		SH3_VAV1_2	786..839	CDD:212909
mug10	NP_593309.2	RhoGEF	52..205	CDD:459876	40/180 (22%)