DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment VASP and ena

DIOPT Version :10

Sequence 1:NP_003361.1 Gene:VASP / 7408 HGNCID:12652 Length:380 Species:Homo sapiens
Sequence 2:NP_001137709.1 Gene:ena / 37201 FlyBaseID:FBgn0000578 Length:980 Species:Drosophila melanogaster


Alignment Length:702 Identity:189/702 - (26%)
Similarity:245/702 - (34%) Gaps:345/702 - (49%)


- Green bases have known domain annotations that are detailed below.


Human     2 SETVICSSRATVMLYDDGNKRWLPAGTGPQAFSRVQIYHNPTANSFRVVGRKMQPDQQVVINCAI 66
            :|..|..:||:||:|||..|:|:|:|:. ...|:|||||:...|:|||||||:| |.:|||||:|
  Fly   298 AEQSIIGARASVMVYDDNQKKWVPSGSS-SGLSKVQIYHHQQNNTFRVVGRKLQ-DHEVVINCSI 360

Human    67 VRGVKYNQATPNFHQWRDARQVWGLNFGSKEDAAQFAAGMASALEALEG------GGP------- 118
            ::|:||||||..||||||::.|:||||.|:.||..||..|..|||.|.|      |||       
  Fly   361 LKGLKYNQATATFHQWRDSKFVYGLNFSSQNDAENFARAMMHALEVLSGRVANNPGGPPTNGNGY 425

Human   119 -------------------------------------------PPPPALP-----TWSVPNGPSP 135
                                                       |..|..|     |.|.|..|.|
  Fly   426 EEDMGYRTMTSEDAAILRQNNSIGGHVTPSAQTPTSQTNQNNIPQSPPTPQGHHRTSSAPPAPQP 490

Human   136 EEVEQQKRQQ------------------------------PGPSEHIERR--------------- 155
            ::.:||::.|                              |.|.:..:::               
  Fly   491 QQQQQQQQAQQMGQPGSHYGPTGNGPTSNGLPQQVNSQIPPAPQQQPQQQQFQQQQQQQQYQQMV 555

Human   156 ----------------VSNA--------------------------------------------- 159
                            :||:                                             
  Fly   556 QAGYAPSQQYQQPHYVLSNSNPNLTVHQYPTQQAQQQPPQAPQPPLQNGGMYMVGHGHLPSSASA 620

Human   160 ------------------------------GGPPAPP----AGGP------PPP----------- 173
                                          ||||.||    |..|      |||           
  Fly   621 NSVVYASQQQMLPQAHPQAPQAPTMPGPGYGGPPVPPPQQQAENPYGQVPMPPPMNPSQQQQPGQ 685

Human   174 -----------PGPPPPPGPPPPP---------GLPPSGVPAAAHGA------GGGPPPAPPLPA 212
                       ||.||.|.|||||         |.||...|...:||      |||||||||.|.
  Fly   686 VPLNRMSSQGGPGGPPAPAPPPPPPSFGGAAGGGPPPPAPPQMFNGAPPPPAMGGGPPPAPPAPP 750

Human   213 AQG------PGGGGA-----------GAP-----------GLAAAIAGAKLRK---VSKQEEASG 246
            |.|      |||.||           |||           .||:.:...||:|   .:...|.||
  Fly   751 AMGGGPPPAPGGPGAPPPPPPPPGLGGAPKKEDPQADLMGSLASQLQQIKLKKNKVTTSAPENSG 815

Human   247 GPTAPKAES-----GRSGGG--GLMEEMNAMLARRRKATQVGEKTPKDESANQEEPEARVPAQSE 304
            ..|:.....     |||..|  .:|:||...|||||  .|..:|.|        :|||.|.    
  Fly   816 SSTSSGGSGNYGTIGRSSNGMASMMDEMAKTLARRR--AQAEKKDP--------DPEAEVK---- 866

Human   305 SVRRPWEKNSTTLPRMKS----------------------SSSVTTSETQPCTP------SSSDY 341
              :||||| |.|||...|                      .|:.|.|..:...|      |:|:.
  Fly   867 --KRPWEK-SNTLPHKLSGGAGSGSAGSGHEGANGNSGGAGSNTTNSGGESPRPMRKRFGSASEE 928

Human   342 S----------------DLQRVKQELLEEVKKELQKVKEEIIEAFVQELRKR 377
            :                ||..:|.|::.|::.|:||||.|||:|...|..:|
  Fly   929 TILKVNGDGLSLALSNGDLDTLKAEIVREMRLEIQKVKNEIIDAIKSEFNRR 980

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VASPNP_003361.1 EVH1_Ena_VASP-like 5..113 CDD:269918 61/107 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 111..343 112/557 (20%)
WH2_hVASP-like 219..245 CDD:409225 11/50 (22%)
EVH2 225..377 59/205 (29%)
EVH2 block A 225..245 6/22 (27%)
KLKR 234..237 2/2 (100%)
actin-binding sequence 235..238 CDD:409225 2/5 (40%)
EVH2 block B 259..278 9/20 (45%)
VASP_tetra 342..376 CDD:462599 15/49 (31%)
EVH2 block C 343..377 15/33 (45%)
2 X 15 AA tandem repeats of L-[EQ]-[KR]-[MV]-K-[EQ]-E-[IL]-[IL]-E-[AEV]-[FV]-[KRV]- [KQ]-E 344..373 13/28 (46%)
enaNP_001137709.1 EVH1_Ena_VASP-like 301..408 CDD:269918 61/108 (56%)
VASP_tetra 946..979 CDD:462599 15/32 (47%)

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