DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VARS1 and GstD3

DIOPT Version :9

Sequence 1:	XP_005249419.1	Gene:	VARS1 / 7407	HGNCID:	12651	Length:	1265	Species:	Homo sapiens
Sequence 2:	NP_788656.1	Gene:	GstD3 / 48336	FlyBaseID:	FBgn0010039	Length:	199	Species:	Drosophila melanogaster

Alignment Length:	152	Identity:	36/152 - (23%)
Similarity:	59/152 - (38%)	Gaps:	29/152 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    53 PPPRLPALEQGPGGLWVWGATAVA----------QLLWPAGLGGPGGSRAAVLVQQWVSYADTEL 107
            |...:|.|..  .|..:|.:.|:.          ..|:|..:     .:.||:.|:  .|.|..|
  Fly    32 PQHSIPTLVD--NGFTIWESRAILVYLVEKYGKDDALYPKDI-----QKQAVINQR--LYFDMAL 87

Human   108 I-PAACGATLPAL--GLRSSAQDPQAVLGALGRALSPLEEWLRLHTYLAGEAPTLADLAAVTALL 169
            : |........|.  |...|.:|.:.|    ......|..:|....|:||:..|:||: |:.|.:
  Fly    88 MYPTLANYYYKAFTTGQFGSEEDYKKV----QETFDFLNTFLEGQDYVAGDQYTVADI-AILANV 147

Human   170 LPFRYVLDPPARRIWNNVTRWF 191
            ..|..|....::  :.||.||:
  Fly   148 SNFDVVGFDISK--YPNVARWY 167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VARS1	XP_005249419.1	GstA	<56..203	CDD:223698	35/149 (23%)
		GST_C_ValRS_N	92..213	CDD:198327	28/103 (27%)
		PTZ00419	283..1265	CDD:240411
		ValRS_core	336..939	CDD:185677
		tRNA-synt_1_2	514..>610	CDD:290334
		Anticodon_Ia_Val	939..1076	CDD:153416
		Val_tRNA-synt_C	1197..1259	CDD:287436
GstD3	NP_788656.1	GST_N_Delta_Epsilon	<1..58	CDD:239343	6/27 (22%)
		GstA	6..173	CDD:223698	36/152 (24%)
		GST_C_Delta_Epsilon	72..188	CDD:198287	28/105 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810