DRSC/TRiP Functional Genomics Resources

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Protein Alignment VARS1 and eEF1gamma

DIOPT Version :9

Sequence 1:XP_005249419.1 Gene:VARS1 / 7407 HGNCID:12651 Length:1265 Species:Homo sapiens
Sequence 2:NP_001189308.1 Gene:eEF1gamma / 44791 FlyBaseID:FBgn0029176 Length:431 Species:Drosophila melanogaster


Alignment Length:482 Identity:127/482 - (26%)
Similarity:202/482 - (41%) Gaps:128/482 - (26%)


- Green bases have known domain annotations that are detailed below.


Human     3 TLYVSPHPDAFPSLRALIAARYGEAGEGPGWGGAHPRIC--LQPPPTSRT-----PFPPPRLPAL 60
            |||.  :|:.|.:.:|||||:|         .||..::.  .:...|:::     .||..::||.
  Fly     5 TLYT--YPENFRAYKALIAAQY---------SGAQVKVADNFKFGETNKSAEFLKKFPGGKVPAF 58

Human    61 EQGPGGLWVWGATAVAQLLWPAGLGGPGGSRAAVLVQQWVSYADTELIPAACGATLPALGL---- 121
            |... |.::..:.|:|.||....|.|.........||||:|:||.|::||:|....|.||:    
  Fly    59 ETAE-GQYLSESNAIAYLLANEQLRGGKCPFVQAQVQQWISFADNEIVPASCAWVFPLLGILPQQ 122

Human   122 --RSSAQDPQAVLGALGRALSPLEEWLRLHTYLAGEAPTLADLAAVTALLLPFRYVLDPPARRIW 184
              .::.|:.:|||..|.:.|...       |:||||..||||:...::||..:.|||:|..|..:
  Fly   123 KNSTAKQEAEAVLQQLNQKLQDA-------TFLAGERITLADIVVFSSLLHLYEYVLEPSVRSAF 180

Human   185 NNVTRWFVTCVRQPEFRAVLGEVVLYSGARPLSHQPGPEAPALPKT-AAQLKKEAKKREKLEKFQ 248
            .||.|||||.:.|.:.:||:.:..|...|  |...|...|....|| ||:.:::|:::::.:|.:
  Fly   181 GNVNRWFVTILNQKQVQAVVKDYKLCEKA--LVFDPKKYAEFQAKTGAAKPQQQAQQQKQEKKPK 243

Human   249 QKQKIQQQQPPPGEQKKPKPE----KREKRDP------GVITYDLPTPPGEKKDVSGPMPDSYSP 303
            :|::..::...|.|:.....|    :.:.:||      |...:|      :.|.|.....::.|.
  Fly   244 EKKEAPKKAAEPAEELDAADEALAAEPKSKDPFDALPKGTFNFD------DFKRVYSNEDEAKSI 302

Human   304 RY----VEAAWYPWWEQQGFFKPEYGRPNVSAANPRGVFMMCIPPPNVTGSLHLGHALTNAIQDS 364
            .|    .:|..|..|..:..:..|..:          |||.|                 |.|...
  Fly   303 PYFFDKFDAENYSIWFGEYKYNEELSK----------VFMSC-----------------NLITGM 340

Human   365 LTRWHRMR-------------GETTLWNPGCDHAGIATQVVVEKKLWREQGLSRHQLGREAFL-- 414
            ..|..:||             |.:|:       :||        .:||.|.|        ||.  
  Fly   341 FQRLDKMRKAAFASVCLFGEDGNSTI-------SGI--------WVWRGQDL--------AFTLS 382

Human   415 ------QEVWKWKEEKGDRIYHQLKKL 435
                  .||:.||  |.|....:.|||
  Fly   383 PDWQIDYEVYDWK--KLDAKSEETKKL 407

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VARS1XP_005249419.1 GstA <56..203 CDD:223698 54/152 (36%)
GST_C_ValRS_N 92..213 CDD:198327 47/126 (37%)
PTZ00419 283..1265 CDD:240411 36/178 (20%)
ValRS_core 336..939 CDD:185677 28/121 (23%)
tRNA-synt_1_2 514..>610 CDD:290334
Anticodon_Ia_Val 939..1076 CDD:153416
Val_tRNA-synt_C 1197..1259 CDD:287436
eEF1gammaNP_001189308.1 GST_N_EF1Bgamma 4..79 CDD:239342 24/85 (28%)
GstA 5..187 CDD:223698 65/200 (33%)
GST_C_EF1Bgamma_like 90..209 CDD:198290 47/125 (38%)
EF1G 271..376 CDD:279041 27/152 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0625
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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