DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VARS1 and GstE12

DIOPT Version :9

Sequence 1:	XP_005249419.1	Gene:	VARS1 / 7407	HGNCID:	12651	Length:	1265	Species:	Homo sapiens
Sequence 2:	NP_001246500.1	Gene:	GstE12 / 37960	FlyBaseID:	FBgn0027590	Length:	223	Species:	Drosophila melanogaster

Alignment Length:	192	Identity:	45/192 - (23%)
Similarity:	67/192 - (34%)	Gaps:	66/192 - (34%)

- Green bases have known domain annotations that are detailed below.

Human   560 LKGKNVIHPFL----SRSLPIVFDEFVDMDFGTGAVKITPAH-------------DQNDY--EVG 605
            |||:::...||    ..::|.:.|         |...|..:|             :|..|  |:.
  Fly    37 LKGEHLTPEFLKLNPQHTIPTLID---------GEATIIDSHAICAYLVEKYGQKEQQLYPKELV 92

Human   606 QRHGLEAISIMDSRGALINVPPPFLGLPRFEARKAVLVALKERGLFRGIEDNPMVVPLCNRSK-- 668
            ||..::|...:|| |.|.                |.|..|.|..|:.|..|       |:..|
  Fly    93 QRANVDARLHLDS-GHLF----------------ARLRFLYEPILYYGSTD-------CSIDKIA 133

Human   669 ------DVVEPLLRPQWYVRCGEMAQAAS----AAVTR-GDLRILPEAHQRTWHAWMDNIRE 719
                  :::|..|:.|.|: ||.....|.    |.||. .|...:.|......|||:..:.|
  Fly   134 YIQKCWEILEGFLKDQPYL-CGSDLTIADFCAVATVTSVNDTAPIDEFKFPKMHAWLKRLAE 194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VARS1	XP_005249419.1	GstA	<56..203	CDD:223698
		GST_C_ValRS_N	92..213	CDD:198327
		PTZ00419	283..1265	CDD:240411	45/192 (23%)
		ValRS_core	336..939	CDD:185677	45/192 (23%)
		tRNA-synt_1_2	514..>610	CDD:290334	15/68 (22%)
		Anticodon_Ia_Val	939..1076	CDD:153416
		Val_tRNA-synt_C	1197..1259	CDD:287436
GstE12	NP_001246500.1	GST_N_Delta_Epsilon	4..77	CDD:239343	10/48 (21%)
		GstA	6..201	CDD:223698	45/192 (23%)
		GST_C_Delta_Epsilon	92..210	CDD:198287	32/128 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810