DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VARS1 and GstT1

DIOPT Version :9

Sequence 1:	XP_005249419.1	Gene:	VARS1 / 7407	HGNCID:	12651	Length:	1265	Species:	Homo sapiens
Sequence 2:	NP_610509.2	Gene:	GstT1 / 35995	FlyBaseID:	FBgn0050000	Length:	228	Species:	Drosophila melanogaster

Alignment Length:	123	Identity:	27/123 - (21%)
Similarity:	44/123 - (35%)	Gaps:	36/123 - (29%)

- Green bases have known domain annotations that are detailed below.

Human   750 PDGRYWVSGRNEAEAREKAAKEFGVSPDK---ISLQQDEDVLDTWFSSGLF---PLSILGWPNQS 808
            |....|:            |.:.|.:|.:   ::|::.|.:.|.:.|...|   |..:.|.....
  Fly    15 PSRALWI------------AMKLGKTPFEDCPVALRKQEQLTDEYRSINRFQKVPAIVDGKFQLG 67

Human   809 EDLSV-------------FYPGTLLETGH-DILFFWVARMVMLGLKLTGRLPFREVYL 852
            |.:|:             .||.||.|... |....|    ....::|...|.||:|:|
  Fly    68 ESVSIVRYLADKGVFSEQLYPKTLEERARVDEFLEW----QHFNVRLVCSLFFRQVWL 121

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VARS1	XP_005249419.1	GstA	<56..203	CDD:223698
		GST_C_ValRS_N	92..213	CDD:198327
		PTZ00419	283..1265	CDD:240411	27/123 (22%)
		ValRS_core	336..939	CDD:185677	27/123 (22%)
		tRNA-synt_1_2	514..>610	CDD:290334
		Anticodon_Ia_Val	939..1076	CDD:153416
		Val_tRNA-synt_C	1197..1259	CDD:287436
GstT1	NP_610509.2	GstA	5..204	CDD:223698	27/123 (22%)
		GST_N_Theta	5..80	CDD:239348	14/76 (18%)
		GST_C_Theta	93..218	CDD:198292	9/33 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900