DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VARS1 and GstE13

DIOPT Version :9

Sequence 1:	XP_005249419.1	Gene:	VARS1 / 7407	HGNCID:	12651	Length:	1265	Species:	Homo sapiens
Sequence 2:	NP_001188889.1	Gene:	GstE13 / 35928	FlyBaseID:	FBgn0033381	Length:	226	Species:	Drosophila melanogaster

Alignment Length:	179	Identity:	40/179 - (22%)
Similarity:	65/179 - (36%)	Gaps:	52/179 - (29%)

- Green bases have known domain annotations that are detailed below.

Human   575 PIVF--DEFVDMDFGTGAVKITPAHD-----QNDYEVGQRHGLEAISIMDSRGALINVPPPFLG- 631
            |:.|  .|.:..:|    ||:.|.|.     .:|.||          .:||...:..:...:.|
  Fly    33 PVDFAKKEHLSEEF----VKLNPQHQIPVFVDSDGEV----------YVDSHAIVCFLVAKYAGN 83

Human   632 ---LPRFEARKA---------------VLVALKERGLFRGI-EDNPMVVPLCNRSKDVVEPLLRP 677
               .||...|:|               |:..:..|.::.|. |.||..:.||:.:...:|..|:.
  Fly    84 DQLYPRDLKRRAHIDHRMHYENGVLFQVVKDIVARNIYGGEGEYNPRSLTLCHNAYSDLEHFLQQ 148

Human   678 QWYVRCGEMAQA-ASAAVTRGDLRIL--------PEAHQRTWHAWMDNI 717
            ..:|...|::.| .|...|...|.:|        |:..|  |...||.:
  Fly   149 GSFVVGNELSVADVSIHTTLVTLDLLIPVEREKYPQTKQ--WMERMDKL 195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VARS1	XP_005249419.1	GstA	<56..203	CDD:223698
		GST_C_ValRS_N	92..213	CDD:198327
		PTZ00419	283..1265	CDD:240411	40/179 (22%)
		ValRS_core	336..939	CDD:185677	40/179 (22%)
		tRNA-synt_1_2	514..>610	CDD:290334	11/41 (27%)
		Anticodon_Ia_Val	939..1076	CDD:153416
		Val_tRNA-synt_C	1197..1259	CDD:287436
GstE13	NP_001188889.1	GST_N_Delta_Epsilon	4..78	CDD:239343	13/58 (22%)
GstE13	NP_001188889.1	GST_C_Delta_Epsilon	92..211	CDD:198287	24/106 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810